Bithionol

DERMATOLOGICALS

Key facts

Bithionol is a drug catalogued in DrugCentral. DrugCentral lists 35 molecular targets, including TTR, MAPK14 and MAPK1.

• Molecular targets: TTR, MAPK14, MAPK1 and ADORA3 (35 listed in DrugCentral).
• ATC code: D10AB01 (Preparations containing sulfur).
• Molecular formula: C12H6Cl4O2S; molecular weight 356.06 g/mol.

Mechanism & targets

Molecular targets (35)

Target	Gene	Action	Activity
Transthyretin	TTR	unknown	Kd 7.21
Mitogen-activated protein kinase 14	MAPK14	unknown	IC50 6.50
Mitogen-activated protein kinase 1	MAPK1	unknown	IC50 6.42
Adenosine receptor A3	ADORA3	unknown	Ki 6.33
Alpha-2B adrenergic receptor	ADRA2B	unknown	Ki 6.25
Epidermal growth factor receptor	EGFR	unknown	IC50 6.21
Alpha-2C adrenergic receptor	ADRA2C	unknown	Ki 6.20
Adenosine receptor A2a	ADORA2A	unknown	Ki 6.18
Potassium channel subfamily T member 1	Kcnt1	activator	EC50 6.00
Sodium-dependent noradrenaline transporter	SLC6A2	unknown	Ki 5.91
D(3) dopamine receptor	DRD3	unknown	Ki 5.84
Alpha-2A adrenergic receptor	ADRA2A	unknown	Ki 5.84
Substance-K receptor	TACR2	unknown	Ki 5.81
Sodium-dependent dopamine transporter	SLC6A3	unknown	Ki 5.76
Thromboxane-A synthase	TBXAS1	unknown	IC50 5.74
Solute carrier family 22 member 2	SLC22A2	unknown	IC50 5.72
Receptor tyrosine-protein kinase erbB-2	ERBB2	unknown	IC50 5.67
Mu-type opioid receptor	OPRM1	unknown	Ki 5.65
Tyrosine-protein kinase Lck	LCK	unknown	IC50 5.65
5-hydroxytryptamine receptor 1A	HTR1A	unknown	Ki 5.50

ATC classification

ATC code	Therapeutic hierarchy
D10AB01	DERMATOLOGICALS › ANTI-ACNE PREPARATIONS › ANTI-ACNE PREPARATIONS FOR TOPICAL USE › Preparations containing sulfur
P02BX01	ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS › ANTHELMINTICS › ANTITREMATODALS › Other antitrematodal agents

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Bithionol is on its molecule page.

• Molecular formula: C₁₂H₆Cl₄O₂S
• Molecular weight: 356.06 g/mol
• CAS number: —
• InChIKey: JFIOVJDNOJYLKP-UHFFFAOYSA-N
• PubChem CID: 2406

OC1=C(SC2=C(O)C(Cl)=CC(Cl)=C2)C=C(Cl)C=C1Cl

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Bithionol work?

Its molecular targets in DrugCentral include TTR, MAPK14, MAPK1 and ADORA3.

What is the chemical formula of Bithionol?

Bithionol has the molecular formula C12H6Cl4O2S and a molecular weight of 356.06 g/mol.

Sources

• DrugCentral drug card 3032 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL290106 — compound record and bioactivity
• PubChem CID 2406 — chemical identifiers
• DrugBank DB04813 — drug record
• FDA UNII AMT77LS62O — substance identity
• UniProt P02766 (TTR) — target protein
• UniProt Q16539 (MAPK14) — target protein
• UniProt P28482 (MAPK1) — target protein
• UniProt P0DMS8 (ADORA3) — target protein
• UniProt P18089 (ADRA2B) — target protein
• UniProt P00533 (EGFR) — target protein

How this page is built: methodology · editorial policy & corrections.