About Tyrosine-protein phosphatase non-receptor type 11
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) is a protein
from Homo sapiens identified by UniProt accession
Q06124, 593 residues long.
MolForge cross-references it against 0 known binders and
955 disease associations.
Target properties
| Protein name | Tyrosine-protein phosphatase non-receptor type 11 |
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| UniProt accession | Q06124 |
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| Gene | PTPN11 |
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| Organism | Homo sapiens |
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| Length | 593 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (955)
Diseases linked to this target (Open Targets).
- Noonan syndrome · score 0.84
- Juvenile Myelomonocytic Leukemia · score 0.83
- Noonan syndrome with multiple lentigines · score 0.82
- metachondromatosis · score 0.77
- acute myeloid leukemia · score 0.67
- cancer · score 0.60
- rasopathy · score 0.59
- Noonan syndrome and Noonan-related syndrome · score 0.57
- Abnormality of the cardiovascular system · score 0.57
- neuroblastoma · score 0.52
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q06124-F1 | alphafold | PREDICTED | 85.94 | — |
Amino-acid sequence (593 residues)
MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRNGA VTHIKIQNTG DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY PLNCADPTSE RWFHGHLSGK EAEKLLTEKG KHGSFLVRES QSHPGDFVLS VRTGDDKGES NDGKSKVTHV MIRCQELKYD VGGGERFDSL TDLVEHYKKN PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT DKVKQGFWEE FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS RVIVMTTKEV ERGKSKCVKY WPDEYALKEY GVMRVRNVKE SAAHDYTLRE LKLSKVGQGN TERTVWQYHF RTWPDHGVPS DPGGVLDFLE EVHHKQESIM DAGPVVVHCS AGIGRTGTFI VIDILIDIIR EKGVDCDIDV PKTIQMVRSQ RSGMVQTEAQ YRFIYMAVQH YIETLQRRIE EEQKSKRKGH EYTNIKYSLA DQTSGDQSPL PPCTPTPPCA EMREDSARVY ENVGLMQQQK SFR
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