Nefopam

NERVOUS SYSTEM

Key facts

Nefopam is a drug catalogued in DrugCentral. It was first approved by the YEAR INTRODUCED in 1978. DrugCentral lists 7 molecular targets, including SLC6A4, SLC6A2 and HTR2C.

• Molecular targets: SLC6A4, SLC6A2, HTR2C and HTR2B (7 listed in DrugCentral).
• ATC code: N02BG06 (Other analgesics and antipyretics).
• Molecular formula: C17H19NO; molecular weight 253.34 g/mol.

Mechanism & targets

Molecular targets (7)

Target	Gene	Action	Activity
Sodium-dependent serotonin transporter	SLC6A4	unknown	Ki 7.54
Sodium-dependent noradrenaline transporter	SLC6A2	unknown	Ki 7.48
5-hydroxytryptamine receptor 2C	HTR2C	unknown	Ki 7.25
5-hydroxytryptamine receptor 2B	HTR2B	unknown	Ki 6.48
Sodium-dependent dopamine transporter	SLC6A3	unknown	Ki 6.28
5-hydroxytryptamine receptor 2A	HTR2A	unknown	Ki 5.77
Sodium channel protein type 5 subunit alpha	SCN5A	unknown	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1978-01-01	YEAR INTRODUCED	—	—

ATC classification

ATC code	Therapeutic hierarchy
N02BG06	NERVOUS SYSTEM › ANALGESICS › OTHER ANALGESICS AND ANTIPYRETICS › Other analgesics and antipyretics

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Cholestasis	616.7
Hepatocellular injury	554.7
Hepatic cytolysis	456.7
Drug reaction with eosinophilia and systemic symptoms	309.5
Acute kidney injury	305.2
Acute generalised exanthematous pustulosis	300.6
Agranulocytosis	288.7
Rash maculo-papular	266.8
Eosinophilia	260.0
Toxic skin eruption	177.1
Mixed liver injury	168.7
Coma	158.4

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Nefopam is on its molecule page.

• Molecular formula: C₁₇H₁₉NO
• Molecular weight: 253.34 g/mol
• CAS number: 13669-70-0
• InChIKey: RGPDEAGGEXEMMM-UHFFFAOYSA-N
• PubChem CID: 4450

CN1CCOC(C2=CC=CC=C2)C2=CC=CC=C2C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Nefopam work?

Its molecular targets in DrugCentral include SLC6A4, SLC6A2, HTR2C and HTR2B.

When was Nefopam first approved?

Nefopam was first approved by the YEAR INTRODUCED in 1978.

What is the chemical formula of Nefopam?

Nefopam has the molecular formula C17H19NO and a molecular weight of 253.34 g/mol.

Sources

• DrugCentral drug card 1891 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1407915 — compound record and bioactivity
• PubChem CID 4450 — chemical identifiers
• DrugBank DB12293 — drug record
• FDA UNII 4UP8060B7J — substance identity
• UniProt P31645 (SLC6A4) — target protein
• UniProt P23975 (SLC6A2) — target protein
• UniProt P28335 (HTR2C) — target protein
• UniProt P41595 (HTR2B) — target protein
• UniProt Q01959 (SLC6A3) — target protein
• UniProt P28223 (HTR2A) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.