Beta-1 adrenergic receptor (ADRB1)

About Beta-1 adrenergic receptor

Beta-1 adrenergic receptor (ADRB1) is a protein from Homo sapiens identified by UniProt accession P08588, 477 residues long. MolForge cross-references it against 0 known binders and 520 disease associations.

Target properties

Protein name	Beta-1 adrenergic receptor
UniProt accession	P08588
Gene	ADRB1
Organism	Homo sapiens
Length	477 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (520)

Diseases linked to this target (Open Targets).

hypertension · score 0.72
cardiovascular disease · score 0.70
myocardial infarction · score 0.61
essential hypertension · score 0.61
heart failure · score 0.61
open-angle glaucoma · score 0.61
migraine disorder · score 0.61
glaucoma · score 0.61
angina pectoris · score 0.61
atrial fibrillation · score 0.60

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P08588-F1	alphafold	PREDICTED	75.33	—

Amino-acid sequence (477 residues)

MGAGVLVLGA SEPGNLSSAA PLPDGAATAA RLLVPASPPA SLLPPASESP EPLSQQWTAG MGLLMALIVL LIVAGNVLVI VAIAKTPRLQ TLTNLFIMSL ASADLVMGLL VVPFGATIVV WGRWEYGSFF CELWTSVDVL CVTASIETLC VIALDRYLAI TSPFRYQSLL TRARARGLVC TVWAISALVS FLPILMHWWR AESDEARRCY NDPKCCDFVT NRAYAIASSV VSFYVPLCIM AFVYLRVFRE AQKQVKKIDS CERRFLGGPA RPPSPSPSPV PAPAPPPGPP RPAAAAATAP LANGRAGKRR PSRLVALREQ KALKTLGIIM GVFTLCWLPF FLANVVKAFH RELVPDRLFV FFNWLGYANS AFNPIIYCRS PDFRKAFQGL LCCARRAARR RHATHGDRPR ASGCLARPGP PPSPGAASDD DDDDVVGATP PARLLEPWAG CNGGAAADSD SSLDEPCRPG FASESKV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards