Beta-2 adrenergic receptor (ADRB2)

About Beta-2 adrenergic receptor

Beta-2 adrenergic receptor (ADRB2) is a protein from Homo sapiens identified by UniProt accession P07550, 413 residues long. MolForge cross-references it against 0 known binders and 715 disease associations.

Target properties

Protein name	Beta-2 adrenergic receptor
UniProt accession	P07550
Gene	ADRB2
Organism	Homo sapiens
Length	413 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (715)

Diseases linked to this target (Open Targets).

chronic obstructive pulmonary disease · score 0.63
asthma · score 0.61
myocardial infarction · score 0.61
migraine disorder · score 0.61
open-angle glaucoma · score 0.61
hypertension · score 0.61
glaucoma · score 0.61
Sepsis · score 0.60
hypotension · score 0.60
Airway obstruction · score 0.60

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P07550-F1	alphafold	PREDICTED	79.14	—

Amino-acid sequence (413 residues)

MGQPGNGSAF LLAPNGSHAP DHDVTQERDE VWVVGMGIVM SLIVLAIVFG NVLVITAIAK FERLQTVTNY FITSLACADL VMGLAVVPFG AAHILMKMWT FGNFWCEFWT SIDVLCVTAS IETLCVIAVD RYFAITSPFK YQSLLTKNKA RVIILMVWIV SGLTSFLPIQ MHWYRATHQE AINCYANETC CDFFTNQAYA IASSIVSFYV PLVIMVFVYS RVFQEAKRQL QKIDKSEGRF HVQNLSQVEQ DGRTGHGLRR SSKFCLKEHK ALKTLGIIMG TFTLCWLPFF IVNIVHVIQD NLIRKEVYIL LNWIGYVNSG FNPLIYCRSP DFRIAFQELL CLRRSSLKAY GNGYSSNGNT GEQSGYHVEQ EKENKLLCED LPGTEDFVGH QGTVPSDNID SQGRNCSTND SLL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards