Beta-3 adrenergic receptor (ADRB3)

About Beta-3 adrenergic receptor

Beta-3 adrenergic receptor (ADRB3) is a protein from Homo sapiens identified by UniProt accession P13945, 408 residues long. MolForge cross-references it against 0 known binders and 367 disease associations.

Target properties

Protein name	Beta-3 adrenergic receptor
UniProt accession	P13945
Gene	ADRB3
Organism	Homo sapiens
Length	408 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (367)

Diseases linked to this target (Open Targets).

myocardial infarction · score 0.62
overactive bladder · score 0.62
hypertension · score 0.61
pain · score 0.60
hypotension · score 0.60
asthma · score 0.60
Sepsis · score 0.60
heart failure · score 0.59
congestive heart failure · score 0.59
sudden cardiac arrest · score 0.59

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P13945-F1	alphafold	PREDICTED	78.93	—

Amino-acid sequence (408 residues)

MAPWPHENSS LAPWPDLPTL APNTANTSGL PGVPWEAALA GALLALAVLA TVGGNLLVIV AIAWTPRLQT MTNVFVTSLA AADLVMGLLV VPPAATLALT GHWPLGATGC ELWTSVDVLC VTASIETLCA LAVDRYLAVT NPLRYGALVT KRCARTAVVL VWVVSAAVSF APIMSQWWRV GADAEAQRCH SNPRCCAFAS NMPYVLLSSS VSFYLPLLVM LFVYARVFVV ATRQLRLLRG ELGRFPPEES PPAPSRSLAP APVGTCAPPE GVPACGRRPA RLLPLREHRA LCTLGLIMGT FTLCWLPFFL ANVLRALGGP SLVPGPAFLA LNWLGYANSA FNPLIYCRSP DFRSAFRRLL CRCGRRLPPE PCAAARPALF PSGVPAARSS PAQPRLCQRL DGASWGVS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards