Zotepine

NERVOUS SYSTEM

Key facts

Zotepine is a drug catalogued in DrugCentral. DrugCentral lists 36 molecular targets, including HTR1D, HRH1 and HTR2A.

• Molecular targets: HTR1D, HRH1, HTR2A and Htr6 (36 listed in DrugCentral).
• ATC code: N05AX11 (Other antipsychotics).
• Molecular formula: C18H18ClNOS; molecular weight 331.86 g/mol.

Mechanism & targets

Molecular targets (36)

Target	Gene	Action	Activity
5-hydroxytryptamine receptor 1D	HTR1D	antagonist	Ki 9.30
Histamine H1 receptor	HRH1	unknown	Ki 9.21
5-hydroxytryptamine receptor 2A	HTR2A	unknown	Ki 9.04
5-hydroxytryptamine receptor 6	Htr6	antagonist	Ki 8.90
5-hydroxytryptamine receptor 7	Htr7	antagonist	Ki 8.80
5-hydroxytryptamine receptor 2C	HTR2C	unknown	Ki 8.54
5-hydroxytryptamine receptor 7	HTR7	antagonist	Ki 8.40
Alpha-1B adrenergic receptor	ADRA1B	unknown	Ki 8.30
5-hydroxytryptamine receptor 6	HTR6	antagonist	Ki 8.30
Alpha-2B adrenergic receptor	ADRA2B	unknown	Ki 8.27
D(3) dopamine receptor	DRD3	unknown	Ki 8.19
Alpha-1A adrenergic receptor	ADRA1A	unknown	Ki 8.15
D(2) dopamine receptor	DRD2	unknown	Ki 7.96
Muscarinic acetylcholine receptor M1	CHRM1	unknown	Ki 7.75
D(1A) dopamine receptor	DRD1	unknown	Ki 7.54
5-hydroxytryptamine receptor 5A	HTR5A	unknown	Ki 7.54
D(4) dopamine receptor	DRD4	unknown	Ki 7.41
5-hydroxytryptamine receptor 1B	HTR1B	antagonist	Ki 7.20
Sodium-dependent noradrenaline transporter	SLC6A2	inhibitor	IC50 7.15
Muscarinic acetylcholine receptor M3	CHRM3	unknown	Ki 7.14

ATC classification

ATC code	Therapeutic hierarchy
N05AX11	NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Other antipsychotics

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Neuroleptic malignant syndrome	125.0
Psychiatric symptom	63.9
Delusion	55.3
Colitis ischaemic	46.8
Colectomy total	44.8

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Zotepine is on its molecule page.

• Molecular formula: C₁₈H₁₈ClNOS
• Molecular weight: 331.86 g/mol
• CAS number: 26615-21-4
• InChIKey: HDOZVRUNCMBHFH-UHFFFAOYSA-N
• PubChem CID: 5736

CN(C)CCOC1=CC2=C(SC3=CC=C(Cl)C=C13)C=CC=C2

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Zotepine work?

Its molecular targets in DrugCentral include HTR1D (antagonist), HRH1, HTR2A and Htr6 (antagonist).

What is the chemical formula of Zotepine?

Zotepine has the molecular formula C18H18ClNOS and a molecular weight of 331.86 g/mol.

Sources

• DrugCentral drug card 2875 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL285802 — compound record and bioactivity
• PubChem CID 5736 — chemical identifiers
• DrugBank DB09225 — drug record
• FDA UNII U29O83JAZW — substance identity
• UniProt P28221 (HTR1D) — target protein
• UniProt P35367 (HRH1) — target protein
• UniProt P28223 (HTR2A) — target protein
• UniProt P28335 (HTR2C) — target protein
• UniProt P34969 (HTR7) — target protein
• UniProt P35368 (ADRA1B) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.