Clotiapine

NERVOUS SYSTEM

Key facts

Clotiapine is a drug catalogued in DrugCentral. DrugCentral lists 5 molecular targets, including DRD2, Htr2c|Htr2a|Htr2b and Drd2.

• Molecular targets: DRD2, Htr2c|Htr2a|Htr2b, Drd2 and Drd1 (5 listed in DrugCentral).
• ATC code: N05AH06 (Diazepines, oxazepines, thiazepines and oxepines).
• Molecular formula: C18H18ClN3S; molecular weight 343.87 g/mol.

Mechanism & targets

Molecular targets (5)

Target	Gene	Action	Activity
D(2) dopamine receptor	DRD2	unknown	Ki 9.31
Serotonin 2 (5-HT2) receptor	Htr2c|Htr2a|Htr2b	unknown	Ki 9.23
D(2) dopamine receptor	Drd2	unknown	Ki 8.36
D(1A) dopamine receptor	Drd1	unknown	Ki 7.85
Muscarinic acetylcholine receptor	Chrm1|Chrm3|Chrm4|Chrm5|Chrm2	unknown	Ki 6.87

ATC classification

ATC code	Therapeutic hierarchy
N05AH06	NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Diazepines, oxazepines, thiazepines and oxepines

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Sopor	495.3
Drug abuse	406.8
Toxicity to various agents	144.6
Intentional overdose	138.6
Intentional self-injury	128.7
Depressed level of consciousness	127.6
Suicide attempt	120.1
Coma	104.3
Sudden death	89.4
Neuroleptic malignant syndrome	67.0
Poisoning	56.0

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Clotiapine is on its molecule page.

• Molecular formula: C₁₈H₁₈ClN₃S
• Molecular weight: 343.87 g/mol
• CAS number: 2058-52-8
• InChIKey: KAAZGXDPUNNEFN-UHFFFAOYSA-N
• PubChem CID: 16351

CN1CCN(CC1)C1=NC2=CC=CC=C2SC2=C1C=C(Cl)C=C2

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Clotiapine work?

Its molecular targets in DrugCentral include DRD2, Htr2c|Htr2a|Htr2b, Drd2 and Drd1.

What is the chemical formula of Clotiapine?

Clotiapine has the molecular formula C18H18ClN3S and a molecular weight of 343.87 g/mol.

Sources

• DrugCentral drug card 717 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL304902 — compound record and bioactivity
• PubChem CID 16351 — chemical identifiers
• DrugBank DB13256 — drug record
• FDA UNII Z05HCY0X1T — substance identity
• UniProt P14416 (DRD2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.