5-hydroxytryptamine receptor 5A (HTR5A)

About 5-hydroxytryptamine receptor 5A

5-hydroxytryptamine receptor 5A (HTR5A) is a protein from Homo sapiens identified by UniProt accession P47898, 357 residues long. MolForge cross-references it against 0 known binders and 317 disease associations.

Target properties

Protein name	5-hydroxytryptamine receptor 5A
UniProt accession	P47898
Gene	HTR5A
Organism	Homo sapiens
Length	357 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (317)

Diseases linked to this target (Open Targets).

schizophrenia · score 0.59
schizoaffective disorder · score 0.50
post operative nausea and vomiting · score 0.47
depressive disorder · score 0.43
unipolar depression · score 0.37
psychosis · score 0.37
mental or behavioural disorder · score 0.37
movement disorder · score 0.37
obesity · score 0.37
Nausea and vomiting · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P47898-F1	alphafold	PREDICTED	79.64	—

Amino-acid sequence (357 residues)

MDLPVNLTSF SLSTPSPLET NHSLGKDDLR PSSPLLSVFG VLILTLLGFL VAATFAWNLL VLATILRVRT FHRVPHNLVA SMAVSDVLVA ALVMPLSLVH ELSGRRWQLG RRLCQLWIAC DVLCCTASIW NVTAIALDRY WSITRHMEYT LRTRKCVSNV MIALTWALSA VISLAPLLFG WGETYSEGSE ECQVSREPSY AVFSTVGAFY LPLCVVLFVY WKIYKAAKFR VGSRKTNSVS PISEAVEVKD SAKQPQMVFT VRHATVTFQP EGDTWREQKE QRAALMVGIL IGVFVLCWIP FFLTELISPL CSCDIPAIWK SIFLWLGYSN SFFNPLIYTA FNKNYNSAFK NFFSRQH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards