Almotriptan

Serotonin-1b and Serotonin-1d Receptor Agonist — NERVOUS SYSTEM

Key facts

Almotriptan is an ofp drug in the Serotonin-1b and Serotonin-1d Receptor Agonist class catalogued in DrugCentral. It was first approved by the FDA in 2001. Its mechanism of action is classified as Serotonin 1b Receptor Agonists and Serotonin 1d Receptor Agonists. DrugCentral lists 3 molecular targets, including HTR1B, HTR1D and HTR1F. Recorded indications include Migraine.

• Approval status: ofp (first approved 2001 by the FDA).
• Drug class: Serotonin-1b and Serotonin-1d Receptor Agonist.
• Mechanism of action: Serotonin 1b Receptor Agonists; Serotonin 1d Receptor Agonists.
• Molecular targets: HTR1B, HTR1D and HTR1F (3 listed in DrugCentral).
• Indications: Migraine.
• ATC code: N02CC05 (Selective serotonin (5HT1) agonists).
• Molecular formula: C17H25N3O2S; molecular weight 335.47 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Migraine

Contraindications (24)

• Acute nephropathy
• Angina pectoris
• Cardiovascular event risk
• Cerebral ischemia
• Cerebrovascular accident
• Conduction disorder of the heart
• Diabetes mellitus
• Disease of liver
• Disorder of coronary artery
• Familial History of Ischemic Heart Disease
• Hemiplegic migraine
• Hypercholesterolemia
• Hypertensive disorder
• Hypertensive urgency
• Myocardial infarction
• Myocardial ischemia
• Obesity
• Peripheral vascular disease
• Prinzmetal angina
• Raynaud's phenomenon
• Serotonin syndrome
• Smokes tobacco daily
• Transient ischemic attack
• Vascular insufficiency of intestine

Mechanism & targets

• Mechanism of action (MoA): Serotonin 1b Receptor Agonists; Serotonin 1d Receptor Agonists
• Established pharmacologic class: Serotonin-1b and Serotonin-1d Receptor Agonist

Molecular targets (3)

Target	Gene	Action	Activity
5-hydroxytryptamine receptor 1B	HTR1B	agonist	Ki 8.00
5-hydroxytryptamine receptor 1D	HTR1D	agonist	Ki 7.50
5-hydroxytryptamine receptor 1F	HTR1F	agonist	Ki 7.20

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2001-05-07	FDA	—	JANSSEN PHARMS

ATC classification

ATC code	Therapeutic hierarchy
N02CC05	NERVOUS SYSTEM › ANALGESICS › ANTIMIGRAINE PREPARATIONS › Selective serotonin (5HT1) agonists

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Nightmare	1000.6
Sedation	871.2
Nephrolithiasis	723.6
Hyperhidrosis	684.7
Product use in unapproved indication	281.3
Nausea	225.5
Product used for unknown indication	197.9
Drug ineffective	194.2
Off label use	136.7
Medication overuse headache	57.9
Abortion missed	56.6
Failed induction of labour	42.7

Chemical structure

• Molecular formula: C₁₇H₂₅N₃O₂S
• Molecular weight: 335.47 g/mol
• CAS number: 154323-57-6
• InChIKey: WKEMJKQOLOHJLZ-UHFFFAOYSA-N
• PubChem CID: 123606

CN(C)CCC1=CNC2=C1C=C(CS(=O)(=O)N1CCCC1)C=C2

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Almotriptan used for?

DrugCentral lists the following indications for Almotriptan: Migraine.

How does Almotriptan work?

Almotriptan is classified as Serotonin 1b Receptor Agonists and Serotonin 1d Receptor Agonists; its molecular targets in DrugCentral include HTR1B (agonist), HTR1D (agonist) and HTR1F (agonist).

When was Almotriptan first approved?

Almotriptan was first approved by the FDA in 2001.

What drug class does Almotriptan belong to?

Almotriptan is in the Serotonin-1b and Serotonin-1d Receptor Agonist class.

What is the chemical formula of Almotriptan?

Almotriptan has the molecular formula C17H25N3O2S and a molecular weight of 335.47 g/mol.

Sources

• DrugCentral drug card 128 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200521 — compound record and bioactivity
• PubChem CID 123606 — chemical identifiers
• DrugBank DB00918 — drug record
• FDA UNII 1O4XL5SN61 — substance identity
• DailyMed: FDA labels for Almotriptan — current prescribing information (label search)
• UniProt P28222 (HTR1B) — target protein
• UniProt P28221 (HTR1D) — target protein
• UniProt P30939 (HTR1F) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.