5-hydroxytryptamine receptor 1E (HTR1E)

About 5-hydroxytryptamine receptor 1E

5-hydroxytryptamine receptor 1E (HTR1E) is a protein from Homo sapiens identified by UniProt accession P28566, 365 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.

Target properties

Protein name	5-hydroxytryptamine receptor 1E
UniProt accession	P28566
Gene	HTR1E
Organism	Homo sapiens
Length	365 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (50)

Diseases linked to this target (Open Targets).

schizophrenia · score 0.59
schizoaffective disorder · score 0.50
post operative nausea and vomiting · score 0.47
depressive disorder · score 0.43
obesity · score 0.37
movement disorder · score 0.37
psychosis · score 0.37
unipolar depression · score 0.37
mental or behavioural disorder · score 0.37
Nausea and vomiting · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P28566-F1	alphafold	PREDICTED	78.46	—

Amino-acid sequence (365 residues)

MNITNCTTEA SMAIRPKTIT EKMLICMTLV VITTLTTLLN LAVIMAIGTT KKLHQPANYL ICSLAVTDLL VAVLVMPLSI IYIVMDRWKL GYFLCEVWLS VDMTCCTCSI LHLCVIALDR YWAITNAIEY ARKRTAKRAA LMILTVWTIS IFISMPPLFW RSHRRLSPPP SQCTIQHDHV IYTIYSTLGA FYIPLTLILI LYYRIYHAAK SLYQKRGSSR HLSNRSTDSQ NSFASCKLTQ TFCVSDFSTS DPTTEFEKFH ASIRIPPFDN DLDHPGERQQ ISSTRERKAA RILGLILGAF ILSWLPFFIK ELIVGLSIYT VSSEVADFLT WLGYVNSLIN PLLYTSFNED FKLAFKKLIR CREHT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards