Pentoxyverine

RESPIRATORY SYSTEM

Key facts

Pentoxyverine is a drug catalogued in DrugCentral. DrugCentral lists 8 molecular targets, including Sigmar1, SIGMAR1 and PRCP. Recorded indications include Allergic rhinitis, Common cold, Cough and Nasal congestion.

• Molecular targets: Sigmar1, SIGMAR1, PRCP and CHRM1 (8 listed in DrugCentral).
• Indications: Allergic rhinitis, Common cold, Cough, Nasal congestion and Nasal discharge and others.
• ATC code: R05DB05 (Other cough suppressants).
• Molecular formula: C20H31NO3; molecular weight 333.47 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (7)

• Allergic rhinitis
• Common cold
• Cough
• Nasal congestion
• Nasal discharge
• Rhinitis
• Vasomotor rhinitis

Contraindications (39)

• Acidosis
• Acute hepatitis
• Acute nephropathy
• Acute pancreatitis
• Angle-closure glaucoma
• Arterial thrombosis
• Arteriosclerotic vascular disease
• Benign prostatic hyperplasia
• Bladder outflow obstruction
• Bradycardia
• Breastfeeding (mother)
• Chronic heart failure
• Chronic idiopathic constipation
• Chronic myocardial ischemia
• Chronic obstructive lung disease
• Conduction disorder of the heart
• Coronary arteriosclerosis
• Diabetes mellitus
• Disorder of cardiovascular system
• Disorder of coronary artery
• Gastrointestinal obstruction
• Hyperkalemia
• Hypertensive disorder
• Hypertensive urgency
• Hyperthyroidism
• Hyporeninemic hypoaldosteronism
• Hypoxia
• Metabolic acidosis
• Myocardial infarction
• Myocardial ischemia
• + 9 more

Mechanism & targets

Molecular targets (8)

Target	Gene	Action	Activity
Sigma non-opioid intracellular receptor 1	Sigmar1	unknown	Ki 7.96
Sigma non-opioid intracellular receptor 1	SIGMAR1	unknown	Ki 7.71
Lysosomal Pro-X carboxypeptidase	PRCP	unknown	IC50 7.49
Muscarinic acetylcholine receptor M1	CHRM1	unknown	Ki 7.12
Muscarinic acetylcholine receptor M2	CHRM2	unknown	Ki 6.78
Solute carrier family 22 member 1	SLC22A1	unknown	IC50 5.81
Transmembrane protein 97	TMEM97	unknown	Ki 5.71
Sodium-dependent dopamine transporter	Slc6a3	unknown	Ki 5.51

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
R05DB05	RESPIRATORY SYSTEM › COUGH AND COLD PREPARATIONS › COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS › Other cough suppressants

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Schizoaffective disorder	52.6

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Pentoxyverine is on its molecule page.

• Molecular formula: C₂₀H₃₁NO₃
• Molecular weight: 333.47 g/mol
• CAS number: 77-23-6
• InChIKey: CFJMRBQWBDQYMK-UHFFFAOYSA-N
• PubChem CID: 2562

CCN(CC)CCOCCOC(=O)C1(CCCC1)C1=CC=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Pentoxyverine used for?

DrugCentral lists the following indications for Pentoxyverine: Allergic rhinitis, Common cold, Cough, Nasal congestion, Nasal discharge, Rhinitis and Vasomotor rhinitis.

How does Pentoxyverine work?

Its molecular targets in DrugCentral include Sigmar1, SIGMAR1, PRCP and CHRM1.

What is the chemical formula of Pentoxyverine?

Pentoxyverine has the molecular formula C20H31NO3 and a molecular weight of 333.47 g/mol.

Sources

• DrugCentral drug card 494 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1256696 — compound record and bioactivity
• PubChem CID 2562 — chemical identifiers
• DrugBank DB11186 — drug record
• FDA UNII 32C726X12W — substance identity
• DailyMed: FDA labels for Pentoxyverine — current prescribing information (label search)
• UniProt Q99720 (SIGMAR1) — target protein
• UniProt P42785 (PRCP) — target protein
• UniProt P11229 (CHRM1) — target protein
• UniProt P08172 (CHRM2) — target protein
• UniProt O15245 (SLC22A1) — target protein
• UniProt Q5BJF2 (TMEM97) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.