Benzonatate

Non-narcotic Antitussive — RESPIRATORY SYSTEM

Key facts

Benzonatate is a drug in the Non-narcotic Antitussive class catalogued in DrugCentral. It was first approved by the FDA in 1958. DrugCentral lists 1 molecular target, including SCN5A. Recorded indications include Cough.

• Drug class: Non-narcotic Antitussive.
• Molecular targets: SCN5A (1 listed in DrugCentral).
• Indications: Cough.
• ATC code: R05DB01 (Other cough suppressants).
• Molecular formula: C12H17NO2(C2H4O)7-9.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Cough

Mechanism & targets

• Established pharmacologic class: Non-narcotic Antitussive

Molecular targets (1)

Target	Gene	Action	Activity
Sodium channel protein type 5 subunit alpha	SCN5A	unknown	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1958-02-10	FDA	—	PFIZER

ATC classification

ATC code	Therapeutic hierarchy
R05DB01	RESPIRATORY SYSTEM › COUGH AND COLD PREPARATIONS › COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS › Other cough suppressants

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Pneumonia	298.5
Cough	215.2
Bronchitis	193.2
Product dose omission issue	146.2
COVID-19	120.4
Completed suicide	119.3
Death	115.9
Conduction disorder	115.0
Dyspnoea	97.0
Upper respiratory tract infection	94.2
Influenza	90.7
Maternal exposure during pregnancy	88.2

Chemical structure

• Molecular formula: C₁₂H₁₇NO₂(C₂H₄O)₇-9
• Molecular weight: —
• CAS number: 104-31-4
• InChIKey: —
• PubChem CID: 7699

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Benzonatate used for?

DrugCentral lists the following indications for Benzonatate: Cough.

How does Benzonatate work?

Its molecular targets in DrugCentral include SCN5A.

When was Benzonatate first approved?

Benzonatate was first approved by the FDA in 1958.

What drug class does Benzonatate belong to?

Benzonatate is in the Non-narcotic Antitussive class.

What is the chemical formula of Benzonatate?

Benzonatate has the molecular formula C12H17NO2(C2H4O)7-9.

Sources

• DrugCentral drug card 326 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1374379 — compound record and bioactivity
• PubChem CID 7699 — chemical identifiers
• DrugBank DB00868 — drug record
• FDA UNII 5P4DHS6ENR — substance identity
• DailyMed: FDA labels for Benzonatate — current prescribing information (label search)
• UniProt Q14524 (SCN5A) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.