Gefapixant

RESPIRATORY SYSTEM

Key facts

Gefapixant is a drug catalogued in DrugCentral. It was first approved by the PMDA in 2022. DrugCentral lists 1 molecular target, including P2RX3. Recorded indications include Refractory chronic cough.

• Molecular targets: P2RX3 (1 listed in DrugCentral).
• Indications: Refractory chronic cough.
• ATC code: R05DB29 (Other cough suppressants).
• Molecular formula: C14H19N5O4S; molecular weight 353.40 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Refractory chronic cough

Mechanism & targets

Molecular targets (1)

Target	Gene	Action	Activity
P2X purinoceptor 3	P2RX3	antagonist	IC50 7.37

Regulatory approvals (2)

Date	Agency	Marketed as	Applicant	Orphan
2023-09-15	EMA	—	Merck Sharp & Dohme B.V.
2022-01-20	PMDA	—	MSD K.K.

ATC classification

ATC code	Therapeutic hierarchy
R05DB29	RESPIRATORY SYSTEM › COUGH AND COLD PREPARATIONS › COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS › Other cough suppressants

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Gefapixant is on its molecule page.

• Molecular formula: C₁₄H₁₉N₅O₄S
• Molecular weight: 353.40 g/mol
• CAS number: 1015787-98-0
• InChIKey: HLWURFKMDLAKOD-UHFFFAOYSA-N
• PubChem CID: 24764487

COC1=C(C=C(OC2=C(N)N=C(N)N=C2)C(=C1)C(C)C)S(N)(=O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Gefapixant used for?

DrugCentral lists the following indications for Gefapixant: Refractory chronic cough.

How does Gefapixant work?

Its molecular targets in DrugCentral include P2RX3 (antagonist).

When was Gefapixant first approved?

Gefapixant was first approved by the PMDA in 2022.

What is the chemical formula of Gefapixant?

Gefapixant has the molecular formula C14H19N5O4S and a molecular weight of 353.40 g/mol.

Sources

• DrugCentral drug card 5519 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL3716057 — compound record and bioactivity
• PubChem CID 24764487 — chemical identifiers
• DrugBank DB15097 — drug record
• FDA UNII 6K6L7E3F1L — substance identity
• UniProt P56373 (P2RX3) — target protein

How this page is built: methodology · editorial policy & corrections.