About P2X purinoceptor 3
P2X purinoceptor 3 (P2RX3) is a protein
from Homo sapiens identified by UniProt accession
P56373, 397 residues long.
MolForge cross-references it against 0 known binders and
133 disease associations.
Target properties
| Protein name | P2X purinoceptor 3 |
|---|
| UniProt accession | P56373 |
|---|
| Gene | P2RX3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 397 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (133)
Diseases linked to this target (Open Targets).
- Cough · score 0.40
- heel bone mineral density · score 0.16
- triglyceride measurement · score 0.16
- mean corpuscular hemoglobin concentration · score 0.11
- cutaneous melanoma · score 0.10
- idiopathic pulmonary fibrosis · score 0.09
- endometriosis · score 0.08
- eosinophil percentage of leukocytes · score 0.08
- interstitial cystitis · score 0.08
- hepatocellular carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P56373-F1 | alphafold | PREDICTED | 88.44 | — |
Amino-acid sequence (397 residues)
MNCISDFFTY ETTKSVVVKS WTIGIINRVV QLLIISYFVG WVFLHEKAYQ VRDTAIESSV VTKVKGSGLY ANRVMDVSDY VTPPQGTSVF VIITKMIVTE NQMQGFCPES EEKYRCVSDS QCGPERLPGG GILTGRCVNY SSVLRTCEIQ GWCPTEVDTV ETPIMMEAEN FTIFIKNSIR FPLFNFEKGN LLPNLTARDM KTCRFHPDKD PFCPILRVGD VVKFAGQDFA KLARTGGVLG IKIGWVCDLD KAWDQCIPKY SFTRLDSVSE KSSVSPGYNF RFAKYYKMEN GSEYRTLLKA FGIRFDVLVY GNAGKFNIIP TIISSVAAFT SVGVGTVLCD IILLNFLKGA DQYKAKKFEE VNETTLKIAA LTNPVYPSDQ TTAEKQSTDS GAFSIGH
Explore P2X purinoceptor 3 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets