Iclaprim

ANTIINFECTIVES FOR SYSTEMIC USE

Key facts

Iclaprim is a drug catalogued in DrugCentral. DrugCentral lists 5 molecular targets, including folA, folA and dfrA17.

• Molecular targets: folA, folA, dfrA17 and DHFR (5 listed in DrugCentral).
• ATC code: J01EA03 (Trimethoprim and derivatives).
• Molecular formula: C19H22N4O3; molecular weight 354.41 g/mol.

Mechanism & targets

Molecular targets (5)

Target	Gene	Action	Activity
Dihydrofolate reductase	folA	unknown	Ki 10.10
Dihydrofolate reductase	folA	unknown	IC50 8.15
Dihydrofolate reductase	dfrA17	unknown	IC50 8.15
Dihydrofolate reductase	DHFR	unknown	Ki 6.11
Dihydrofolate reductase	—	unknown	IC50 5.62

ATC classification

ATC code	Therapeutic hierarchy
J01EA03	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › SULFONAMIDES AND TRIMETHOPRIM › Trimethoprim and derivatives

Chemical structure

• Molecular formula: C₁₉H₂₂N₄O₃
• Molecular weight: 354.41 g/mol
• CAS number: 192314-93-5
• InChIKey: HWJPWWYTGBZDEG-UHFFFAOYSA-N
• PubChem CID: 213043

COC1=CC(CC2=CN=C(N)N=C2N)=C2C=CC(OC2=C1OC)C1CC1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Iclaprim work?

Its molecular targets in DrugCentral include folA, folA, dfrA17 and DHFR.

What is the chemical formula of Iclaprim?

Iclaprim has the molecular formula C19H22N4O3 and a molecular weight of 354.41 g/mol.

Sources

• DrugCentral drug card 4573 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL134561 — compound record and bioactivity
• PubChem CID 213043 — chemical identifiers
• DrugBank DB06358 — drug record
• FDA UNII 42445HUU0O — substance identity
• UniProt P00374 (DHFR) — target protein

How this page is built: methodology · editorial policy & corrections.