About Dihydrofolate reductase
Dihydrofolate reductase (DHFR) is a protein
from Homo sapiens identified by UniProt accession
P00374, 187 residues long.
MolForge cross-references it against 0 known binders and
544 disease associations.
Target properties
| Protein name | Dihydrofolate reductase |
|---|
| UniProt accession | P00374 |
|---|
| Gene | DHFR |
|---|
| Organism | Homo sapiens |
|---|
| Length | 187 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (544)
Diseases linked to this target (Open Targets).
- constitutional megaloblastic anemia with severe neurologic disease · score 0.78
- acute lymphoblastic leukemia · score 0.62
- non-small cell lung carcinoma · score 0.61
- rheumatoid arthritis · score 0.61
- psoriasis · score 0.60
- juvenile idiopathic arthritis · score 0.58
- breast cancer · score 0.58
- psoriatic arthritis · score 0.57
- Crohn's disease · score 0.57
- adult acute lymphoblastic leukemia · score 0.56
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P00374-F1 | alphafold | PREDICTED | 96.13 | — |
Amino-acid sequence (187 residues)
MVGSLNCIVA VSQNMGIGKN GDLPWPPLRN EFRYFQRMTT TSSVEGKQNL VIMGKKTWFS IPEKNRPLKG RINLVLSREL KEPPQGAHFL SRSLDDALKL TEQPELANKV DMVWIVGGSS VYKEAMNHPG HLKLFVTRIM QDFESDTFFP EIDLEKYKLL PEYPGVLSDV QEEKGIKYKF EVYEKND
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