Sulfacetamide

Sulfonamide Antibacterial — DERMATOLOGICALS

Key facts

Sulfacetamide is an ofp drug in the Sulfonamide Antibacterial class catalogued in DrugCentral. It was first approved by the FDA in 1945. DrugCentral lists 3 molecular targets, including DHFR, DHFR and folP. Recorded indications include Acne vulgaris, Amebic infection, Blepharoconjunctivitis and Chlamydial conjunctivitis.

• Approval status: ofp (first approved 1945 by the FDA).
• Drug class: Sulfonamide Antibacterial.
• Molecular targets: DHFR, DHFR and folP (3 listed in DrugCentral).
• Indications: Acne vulgaris, Amebic infection, Blepharoconjunctivitis, Chlamydial conjunctivitis and Gardnerella Vaginalis Bacterial Vaginosis and others.
• ATC code: D10AF06 (Antiinfectives for treatment of acne).
• Molecular formula: C8H10N2O3S; molecular weight 214.24 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (13)

• Acne vulgaris
• Amebic infection
• Blepharoconjunctivitis
• Chlamydial conjunctivitis
• Gardnerella Vaginalis Bacterial Vaginosis
• Infective blepharitis
• Iridocyclitis
• Pityriasis simplex
• Seborrheic dermatitis
• Superficial Ocular Infection
• Trachoma
• Uveitis
• Vulvovaginitis

Off-label uses (3)

• Bacterial conjunctivitis
• Bacterial keratitis
• Rosacea

Contraindications (32)

• Anemia due to enzyme deficiency
• Angle-closure glaucoma
• Arterial aneurysm
• Arteriosclerotic vascular disease
• Bacterial infection of eye
• Benign prostatic hyperplasia
• Breastfeeding (mother)
• Conduction disorder of the heart
• Deficiency of glucose-6-phosphate dehydrogenase
• Denuded skin
• Diabetes mellitus
• Disease of blood AND/OR blood-forming organ
• Disease of liver
• Disorder of coronary artery
• Eruption of skin
• Eye infection
• Fungal infection of eye
• Heart disease
• Herpes simplex dendritic keratitis
• Herpes simplex keratitis
• Hypertensive disorder
• Hyperthyroidism
• Kidney disease
• Krukenberg spindle
• Ocular hypertension
• Open-angle glaucoma
• Porphyria
• Severe myopia
• Skin irritation
• Tuberculosis of eye
• + 2 more

Mechanism & targets

• Established pharmacologic class: Sulfonamide Antibacterial

Molecular targets (3)

Target	Gene	Action	Activity
Dihydrofolate reductase	DHFR	unknown	IC50 4.74
Dihydrofolate reductase	DHFR	unknown	IC50 4.66
Dihydropteroate synthase	folP	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1945-09-12	FDA	—	ORTHO MCNEIL PHARM

ATC classification

ATC code	Therapeutic hierarchy
D10AF06	DERMATOLOGICALS › ANTI-ACNE PREPARATIONS › ANTI-ACNE PREPARATIONS FOR TOPICAL USE › Antiinfectives for treatment of acne
S01AB04	SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIINFECTIVES › Sulfonamides

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Drug hypersensitivity	465.9
Bronchiectasis	174.1
Bone erosion	154.7
Hypothyroidism	140.7
Loss of personal independence in daily activities	97.4
Red blood cell sedimentation rate abnormal	73.4
Neutropenia	67.2
Synovitis	62.9
Hypersensitivity	56.7
Drug intolerance	56.6
Joint stiffness	47.6
Joint surgery	39.3

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Sulfacetamide is on its molecule page.

• Molecular formula: C₈H₁₀N₂O₃S
• Molecular weight: 214.24 g/mol
• CAS number: 144-80-9
• InChIKey: SKIVFJLNDNKQPD-UHFFFAOYSA-N
• PubChem CID: 5320

CC(=O)NS(=O)(=O)C1=CC=C(N)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Sulfacetamide used for?

DrugCentral lists the following indications for Sulfacetamide: Acne vulgaris, Amebic infection, Blepharoconjunctivitis, Chlamydial conjunctivitis, Gardnerella Vaginalis Bacterial Vaginosis, Infective blepharitis, Iridocyclitis and Pityriasis simplex and others.

How does Sulfacetamide work?

Its molecular targets in DrugCentral include DHFR, DHFR and folP (inhibitor).

When was Sulfacetamide first approved?

Sulfacetamide was first approved by the FDA in 1945.

What drug class does Sulfacetamide belong to?

Sulfacetamide is in the Sulfonamide Antibacterial class.

What is the chemical formula of Sulfacetamide?

Sulfacetamide has the molecular formula C8H10N2O3S and a molecular weight of 214.24 g/mol.

Sources

• DrugCentral drug card 2497 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1723241 — compound record and bioactivity
• PubChem CID 5320 — chemical identifiers
• DrugBank DB00634 — drug record
• FDA UNII 4965G3J0F5 — substance identity
• DailyMed: FDA labels for Sulfacetamide — current prescribing information (label search)
• UniProt P00374 (DHFR) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.