About Lysosomal Pro-X carboxypeptidase
Lysosomal Pro-X carboxypeptidase (PRCP) is a protein
from Homo sapiens identified by UniProt accession
P42785, 496 residues long.
MolForge cross-references it against 0 known binders and
72 disease associations.
Target properties
| Protein name | Lysosomal Pro-X carboxypeptidase |
|---|
| UniProt accession | P42785 |
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| Gene | PRCP |
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| Organism | Homo sapiens |
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| Length | 496 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (72)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.37
- adolescent idiopathic scoliosis · score 0.29
- lung adenocarcinoma · score 0.23
- glioblastoma multiforme · score 0.21
- squamous cell lung carcinoma · score 0.19
- cutaneous melanoma · score 0.18
- breast adenocarcinoma · score 0.13
- head and neck squamous cell carcinoma · score 0.11
- gastric adenocarcinoma · score 0.10
- triple-negative breast cancer · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P42785-F1 | alphafold | PREDICTED | 90.60 | — |
Amino-acid sequence (496 residues)
MGRRALLLLL LSFLAPWATI ALRPALRALG SLHLPTNPTS LPAVAKNYSV LYFQQKVDHF GFNTVKTFNQ RYLVADKYWK KNGGSILFYT GNEGDIIWFC NNTGFMWDVA EELKAMLVFA EHRYYGESLP FGDNSFKDSR HLNFLTSEQA LADFAELIKH LKRTIPGAEN QPVIAIGGSY GGMLAAWFRM KYPHMVVGAL AASAPIWQFE DLVPCGVFMK IVTTDFRKSG PHCSESIHRS WDAINRLSNT GSGLQWLTGA LHLCSPLTSQ DIQHLKDWIS ETWVNLAMVD YPYASNFLQP LPAWPIKVVC QYLKNPNVSD SLLLQNIFQA LNVYYNYSGQ VKCLNISETA TSSLGTLGWS YQACTEVVMP FCTNGVDDMF EPHSWNLKEL SDDCFQQWGV RPRPSWITTM YGGKNISSHT NIVFSNGELD PWSGGGVTKD ITDTLVAVTI SEGAHHLDLR TKNALDPMSV LLARSLEVRH MKNWIRDFYD SAGKQH
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