Phencyclidine
Drug profile
Also known as: phencyclidine HCl, phencyclidine hydrobromide, phencyclidine hydrochloride
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Phencyclidine is a drug catalogued in DrugCentral. DrugCentral lists 12 molecular targets, including GRIN2D|GRIN3B|GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN3A, Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3b|Grin3a and Grin1.
- Molecular targets: GRIN2D|GRIN3B|GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN3A, Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3b|Grin3a, Grin1 and Grin2c (12 listed in DrugCentral).
- Molecular formula: C17H25N; molecular weight 243.39 g/mol.
Mechanism & targets
Molecular targets (12)
| Target | Gene | Action | Activity |
|---|---|---|---|
| Glutamate [NMDA] receptor | GRIN2D|GRIN3B|GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN3A | unknown | Ki 7.82 |
| Glutamate NMDA receptor | Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3b|Grin3a | unknown | Ki 7.42 |
| Glutamate receptor ionotropic, NMDA 1 | Grin1 | unknown | Ki 7.28 |
| Glutamate receptor ionotropic, NMDA 2C | Grin2c | unknown | Ki 7.22 |
| Lysosomal Pro-X carboxypeptidase | PRCP | unknown | IC50 7.04 |
| Acetylcholine receptor subunit alpha | CHRNA1 | unknown | IC50 6.66 |
| Glutamate NMDA receptor; GRIN1/GRIN2A | GRIN1|GRIN2A | unknown | IC50 6.40 |
| Sigma non-opioid intracellular receptor 1 | Sigmar1 | unknown | IC50 6.28 |
| Cholinesterase | Bche | unknown | Ki 6.28 |
| Sigma non-opioid intracellular receptor 1 | SIGMAR1 | unknown | Ki 5.96 |
| Glutamate NMDA receptor; GRIN1/GRIN2B | GRIN1|GRIN2B | unknown | IC50 5.90 |
| Muscarinic acetylcholine receptor | Chrm1|Chrm4|Chrm5|Chrm3|Chrm2 | unknown | Kd 5.04 |
Reported adverse-event signals
Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.
| MedDRA term | LLR |
|---|---|
| Drug abuse | 315.1 |
| Toxicity to various agents | 262.2 |
| Completed suicide | 162.1 |
Chemical structure
Full physicochemical, ADMET and 3D-structure analysis of Phencyclidine is on its molecule page.
| Molecular formula | C17H25N |
|---|---|
| Molecular weight | 243.39 g/mol |
| CAS number | — |
| InChIKey | JTJMJGYZQZDUJJ-UHFFFAOYSA-N |
| PubChem CID | 6468 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
How does Phencyclidine work?
Its molecular targets in DrugCentral include GRIN2D|GRIN3B|GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN3A, Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3b|Grin3a, Grin1 and Grin2c.
What is the chemical formula of Phencyclidine?
Phencyclidine has the molecular formula C17H25N and a molecular weight of 243.39 g/mol.
Browse: all drugs starting with P · drug guides by category · protein targets A–Z.
Sources
- DrugCentral drug card 2121 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL275528 — compound record and bioactivity
- PubChem CID 6468 — chemical identifiers
- DrugBank DB03575 — drug record
- FDA UNII J1DOI7UV76 — substance identity
- UniProt P42785 (PRCP) — target protein
- UniProt Q99720 (SIGMAR1) — target protein
- FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral
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