Sotalol

Antiarrhythmic — CARDIOVASCULAR SYSTEM

Key facts

Sotalol is an ofp drug in the Antiarrhythmic class catalogued in DrugCentral. It was first approved by the FDA in 1992. Its mechanism of action is classified as Adrenergic beta-Antagonists. DrugCentral lists 5 molecular targets, including ADRB2, ADRB2 and ADRB1. Recorded indications include Atrial fibrillation and Life-Threatening Ventricular Tachycardia.

• Approval status: ofp (first approved 1992 by the FDA).
• Drug class: Antiarrhythmic.
• Mechanism of action: Adrenergic beta-Antagonists.
• Molecular targets: ADRB2, ADRB2, ADRB1 and ADRB2 (5 listed in DrugCentral).
• Indications: Atrial fibrillation and Life-Threatening Ventricular Tachycardia.
• ATC code: C07AA07 (Beta blocking agents, non-selective).
• Molecular formula: C12H20N2O3S; molecular weight 272.36 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (2)

• Atrial fibrillation
• Life-Threatening Ventricular Tachycardia

Contraindications (18)

• Anaphylaxis
• Asthma
• Bronchospasm
• Cardiogenic shock
• Complete atrioventricular block
• Congenital long QT syndrome
• Decompensated cardiac failure
• Diabetes mellitus
• Hypokalemia
• Hypomagnesemia
• Impaired renal function disorder
• Low blood pressure
• Pregnancy, function
• Prolonged QT interval
• Second degree atrioventricular block
• Sick sinus syndrome
• Sinus bradycardia
• Torsades de pointes

Mechanism & targets

• Mechanism of action (MoA): Adrenergic beta-Antagonists
• Established pharmacologic class: Antiarrhythmic

Molecular targets (5)

Target	Gene	Action	Activity
Beta-2 adrenergic receptor	ADRB2	antagonist	Ki 6.90
Beta-2 adrenergic receptor	ADRB2	unknown	Kd 6.24
Beta-1 adrenergic receptor	ADRB1	antagonist	Ki 6.10
Beta-2 adrenergic receptor	ADRB2	unknown	IC50 5.30
Potassium voltage-gated channel subfamily H member 2	KCNH2	blocker	Ki 4.00

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1992-10-30	FDA	—	COVIS PHARMA SARL	Yes

ATC classification

ATC code	Therapeutic hierarchy
C07AA07	CARDIOVASCULAR SYSTEM › BETA BLOCKING AGENTS › BETA BLOCKING AGENTS › Beta blocking agents, non-selective
C07BA07	CARDIOVASCULAR SYSTEM › BETA BLOCKING AGENTS › BETA BLOCKING AGENTS AND THIAZIDES › Beta blocking agents, non-selective, and thiazides
C07FX02	CARDIOVASCULAR SYSTEM › BETA BLOCKING AGENTS › BETA BLOCKING AGENTS, OTHER COMBINATIONS › Beta blocking agents, other combinations

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Accidental poisoning	1463.7
Electrocardiogram QT prolonged	674.6
Atrial fibrillation	546.5
Torsade de pointes	517.6
Bradycardia	386.0
Ventricular tachycardia	366.6
Drug interaction	210.3
Hypotension	190.2
Arrhythmia	145.4
International normalised ratio increased	138.0
Long QT syndrome	134.5
Palpitations	123.0

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Sotalol is on its molecule page.

• Molecular formula: C₁₂H₂₀N₂O₃S
• Molecular weight: 272.36 g/mol
• CAS number: 3930-20-9
• InChIKey: ZBMZVLHSJCTVON-UHFFFAOYSA-N
• PubChem CID: 5253

CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Sotalol used for?

DrugCentral lists the following indications for Sotalol: Atrial fibrillation and Life-Threatening Ventricular Tachycardia.

How does Sotalol work?

Sotalol is classified as Adrenergic beta-Antagonists; its molecular targets in DrugCentral include ADRB2 (antagonist), ADRB2, ADRB1 (antagonist) and ADRB2.

When was Sotalol first approved?

Sotalol was first approved by the FDA in 1992.

What drug class does Sotalol belong to?

Sotalol is in the Antiarrhythmic class.

What is the chemical formula of Sotalol?

Sotalol has the molecular formula C12H20N2O3S and a molecular weight of 272.36 g/mol.

Sources

• DrugCentral drug card 2464 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1700 — compound record and bioactivity
• PubChem CID 5253 — chemical identifiers
• DrugBank DB00489 — drug record
• FDA UNII A6D97U294I — substance identity
• DailyMed: FDA labels for Sotalol — current prescribing information (label search)
• UniProt P07550 (ADRB2) — target protein
• UniProt P08588 (ADRB1) — target protein
• UniProt Q12809 (KCNH2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.