Metipranolol

beta-Adrenergic Blocker — CARDIOVASCULAR SYSTEM

Key facts

Metipranolol is an ofm drug in the beta-Adrenergic Blocker class catalogued in DrugCentral. It was first approved by the FDA in 1989. Its mechanism of action is classified as Adrenergic beta-Antagonists. DrugCentral lists 2 molecular targets, including ADRB1 and ADRB2. Recorded indications include Ocular hypertension and Open-angle glaucoma.

• Approval status: ofm (first approved 1989 by the FDA).
• Drug class: beta-Adrenergic Blocker.
• Mechanism of action: Adrenergic beta-Antagonists.
• Molecular targets: ADRB1 and ADRB2 (2 listed in DrugCentral).
• Indications: Ocular hypertension and Open-angle glaucoma.
• ATC code: C07BA68 (Beta blocking agents, non-selective, and thiazides).
• Molecular formula: C17H27NO4; molecular weight 309.41 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (2)

• Ocular hypertension
• Open-angle glaucoma

Off-label uses (4)

• Angle-closure glaucoma
• Aphakic glaucoma
• Malignant glaucoma
• Secondary glaucoma

Contraindications (17)

• Acute cerebrovascular insufficiency
• Anaphylaxis
• Asthma
• Cardiogenic shock
• Chronic bronchitis
• Chronic heart failure
• Chronic obstructive lung disease
• Complete atrioventricular block
• Decompensated cardiac failure
• Diabetes mellitus
• Hyperthyroidism
• Myasthenia gravis
• Pregnancy, function
• Pulmonary emphysema
• Second degree atrioventricular block
• Severe chronic obstructive pulmonary disease
• Sinus bradycardia

Mechanism & targets

• Mechanism of action (MoA): Adrenergic beta-Antagonists
• Established pharmacologic class: beta-Adrenergic Blocker

Molecular targets (2)

Target	Gene	Action	Activity
Beta-1 adrenergic receptor	ADRB1	antagonist	—
Beta-2 adrenergic receptor	ADRB2	antagonist	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1989-12-29	FDA	—	BAUSCH AND LOMB

ATC classification

ATC code	Therapeutic hierarchy
C07BA68	CARDIOVASCULAR SYSTEM › BETA BLOCKING AGENTS › BETA BLOCKING AGENTS AND THIAZIDES › Beta blocking agents, non-selective, and thiazides
S01ED04	SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIGLAUCOMA PREPARATIONS AND MIOTICS › Beta blocking agents
S01ED54	SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIGLAUCOMA PREPARATIONS AND MIOTICS › Beta blocking agents

Chemical structure

• Molecular formula: C₁₇H₂₇NO₄
• Molecular weight: 309.41 g/mol
• CAS number: 22664-55-7
• InChIKey: BQIPXWYNLPYNHW-UHFFFAOYSA-N
• PubChem CID: 31477

CC(C)NCC(O)COC1=C(C)C(C)=C(OC(C)=O)C(C)=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Metipranolol used for?

DrugCentral lists the following indications for Metipranolol: Ocular hypertension and Open-angle glaucoma.

How does Metipranolol work?

Metipranolol is classified as Adrenergic beta-Antagonists; its molecular targets in DrugCentral include ADRB1 (antagonist) and ADRB2 (antagonist).

When was Metipranolol first approved?

Metipranolol was first approved by the FDA in 1989.

What drug class does Metipranolol belong to?

Metipranolol is in the beta-Adrenergic Blocker class.

What is the chemical formula of Metipranolol?

Metipranolol has the molecular formula C17H27NO4 and a molecular weight of 309.41 g/mol.

Sources

• DrugCentral drug card 1779 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200947 — compound record and bioactivity
• PubChem CID 31477 — chemical identifiers
• DrugBank DB01214 — drug record
• FDA UNII X39AL81KEB — substance identity
• DailyMed: FDA labels for Metipranolol — current prescribing information (label search)
• UniProt P08588 (ADRB1) — target protein
• UniProt P07550 (ADRB2) — target protein

How this page is built: methodology · editorial policy & corrections.