Levosulpiride

NERVOUS SYSTEM

Key facts

Levosulpiride is a drug catalogued in DrugCentral. DrugCentral lists 9 molecular targets, including Drd2, DRD2 and DRD3.

• Molecular targets: Drd2, DRD2, DRD3 and Drd1|Drd3|Drd5|Drd4|Drd2 (9 listed in DrugCentral).
• ATC code: N05AL07 (Benzamides).
• Molecular formula: C15H23N3O4S; molecular weight 341.43 g/mol.

Mechanism & targets

Molecular targets (9)

Target	Gene	Action	Activity
D(2) dopamine receptor	Drd2	unknown	Ki 8.16
D(2) dopamine receptor	DRD2	unknown	Ki 7.29
D(3) dopamine receptor	DRD3	unknown	Ki 7.06
Dopamine receptor	Drd1|Drd3|Drd5|Drd4|Drd2	unknown	IC50 6.68
D(4) dopamine receptor	DRD4	unknown	Ki 5.68
Myeloperoxidase	MPO	unknown	IC50 5.12
Adrenergic receptor alpha-1	Adra1b|Adra1d|Adra1a	unknown	Ki 4.82
Serotonin 2 (5-HT2) receptor	Htr2c|Htr2a|Htr2b	unknown	Ki 4.57
D(1A) dopamine receptor	DRD1	unknown	Ki 4.30

ATC classification

ATC code	Therapeutic hierarchy
N05AL07	NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Benzamides

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Sopor	121.5
Cerebellar syndrome	88.6
Disorganised speech	76.8
Galactorrhoea	76.0
Renal ischaemia	74.8
Drug abuse	62.3
Necrotising colitis	58.8
Hyperprolactinaemia	54.2
Serotonin syndrome	53.0
Drug interaction	45.7

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Levosulpiride is on its molecule page.

• Molecular formula: C₁₅H₂₃N₃O₄S
• Molecular weight: 341.43 g/mol
• CAS number: 23672-07-3
• InChIKey: BGRJTUBHPOOWDU-NSHDSACASA-N
• PubChem CID: 688272

CCN1CCC[C@H]1CNC(=O)C1=C(OC)C=CC(=C1)S(N)(=O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Levosulpiride work?

Its molecular targets in DrugCentral include Drd2, DRD2, DRD3 and Drd1|Drd3|Drd5|Drd4|Drd2.

What is the chemical formula of Levosulpiride?

Levosulpiride has the molecular formula C15H23N3O4S and a molecular weight of 341.43 g/mol.

Sources

• DrugCentral drug card 1577 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL267044 — compound record and bioactivity
• PubChem CID 688272 — chemical identifiers
• DrugBank DB16021 — drug record
• FDA UNII JTG7R315LK — substance identity
• UniProt P14416 (DRD2) — target protein
• UniProt P35462 (DRD3) — target protein
• UniProt P21917 (DRD4) — target protein
• UniProt P05164 (MPO) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.