Dapsone

Sulfone — DERMATOLOGICALS

Key facts

Dapsone is an ofp drug in the Sulfone class catalogued in DrugCentral. It was first approved by the FDA in 1979. DrugCentral lists 8 molecular targets, including HTR6, MPO and folP1. Recorded indications include Acne vulgaris, Dermatitis herpetiformis and Leprosy.

• Approval status: ofp (first approved 1979 by the FDA).
• Drug class: Sulfone.
• Molecular targets: HTR6, MPO, folP1 and Dihydrofolate reductase (8 listed in DrugCentral).
• Indications: Acne vulgaris, Dermatitis herpetiformis and Leprosy.
• ATC code: D10AX05 (Other anti-acne preparations for topical use).
• Molecular formula: C12H12N2O2S; molecular weight 248.31 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (3)

• Acne vulgaris
• Dermatitis herpetiformis
• Leprosy

Off-label uses (10)

• Actinomycotic mycetoma
• Benign mucous membrane pemphigoid
• Granuloma annulare
• Pemphigoid
• Pneumocystis Carinii Pneumonia Prevention
• Pneumocystosis jiroveci pneumonia
• Pyoderma gangrenosum
• Subcorneal pustular dermatosis
• Systemic lupus erythematosus
• Toxoplasmosis

Contraindications (5)

• Anemia
• Anemia due to enzyme deficiency
• Deficiency of cytochrome-b>5< reductase
• Deficiency of glucose-6-phosphate dehydrogenase
• Disease of liver

Mechanism & targets

• Established pharmacologic class: Sulfone

Molecular targets (8)

Target	Gene	Action	Activity
5-hydroxytryptamine receptor 6	HTR6	unknown	Ki 6.74
Myeloperoxidase	MPO	unknown	IC50 6.38
Dihydropteroate synthase 1	folP1	inhibitor	IC50 5.90
Dihydrofolate reductase	—	unknown	IC50 5.82
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	PPPK-DHPS	unknown	IC50 4.91
Dihydropteroate synthetase, putative	—	unknown	IC50 4.91
Cytochrome P450 3A4	CYP3A4	unknown	Ki 4.57
Glucose-6-phosphate 1-dehydrogenase	G6PD	unknown	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1979-07-03	FDA	—	JACOBUS

ATC classification

ATC code	Therapeutic hierarchy
D10AX05	DERMATOLOGICALS › ANTI-ACNE PREPARATIONS › ANTI-ACNE PREPARATIONS FOR TOPICAL USE › Other anti-acne preparations for topical use
J04BA02	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIMYCOBACTERIALS › DRUGS FOR TREATMENT OF LEPRA › Drugs for treatment of lepra
J04BA50	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIMYCOBACTERIALS › DRUGS FOR TREATMENT OF LEPRA › Drugs for treatment of lepra
J04BA51	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIMYCOBACTERIALS › DRUGS FOR TREATMENT OF LEPRA › Drugs for treatment of lepra

Pharmacogenomics

Drug-label and guideline annotations from PharmGKB and CPIC.

• FDA label: CYB5R3 · Actionable PGx
• FDA label: G6PD · Actionable PGx
• HCSC label: G6PD · Actionable PGx
• HCSC label: CYB5R3 · Actionable PGx
• PMDA label: G6PD · Actionable PGx

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Methaemoglobinaemia	1956.6
Drug reaction with eosinophilia and systemic symptoms	734.8
Haemolytic anaemia	373.6
Off label use	338.6
Drug ineffective for unapproved indication	251.1
Type 2 lepra reaction	212.9
Drug ineffective	179.5
Treatment failure	159.8
Linear IgA disease	141.3
Haemolysis	138.0
Rebound effect	112.8
Type 1 lepra reaction	105.8

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Dapsone is on its molecule page.

• Molecular formula: C₁₂H₁₂N₂O₂S
• Molecular weight: 248.31 g/mol
• CAS number: —
• InChIKey: MQJKPEGWNLWLTK-UHFFFAOYSA-N
• PubChem CID: 2955

NC1=CC=C(C=C1)S(=O)(=O)C1=CC=C(N)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Dapsone used for?

DrugCentral lists the following indications for Dapsone: Acne vulgaris, Dermatitis herpetiformis and Leprosy.

How does Dapsone work?

Its molecular targets in DrugCentral include HTR6, MPO, folP1 (inhibitor) and Dihydrofolate reductase.

When was Dapsone first approved?

Dapsone was first approved by the FDA in 1979.

What drug class does Dapsone belong to?

Dapsone is in the Sulfone class.

What is the chemical formula of Dapsone?

Dapsone has the molecular formula C12H12N2O2S and a molecular weight of 248.31 g/mol.

Sources

• DrugCentral drug card 782 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1043 — compound record and bioactivity
• PubChem CID 2955 — chemical identifiers
• DrugBank DB00250 — drug record
• FDA UNII 8W5C518302 — substance identity
• DailyMed: FDA labels for Dapsone — current prescribing information (label search)
• UniProt P50406 (HTR6) — target protein
• UniProt P05164 (MPO) — target protein
• UniProt P08684 (CYP3A4) — target protein
• UniProt P11413 (G6PD) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral
• PharmGKB / CPIC — pharmacogenomic label annotations

How this page is built: methodology · editorial policy & corrections.