About Glucose-6-phosphate 1-dehydrogenase
Glucose-6-phosphate 1-dehydrogenase (G6PD) is a protein
from Homo sapiens identified by UniProt accession
P11413, 515 residues long.
MolForge cross-references it against 0 known binders and
120 disease associations.
Target properties
| Protein name | Glucose-6-phosphate 1-dehydrogenase |
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| UniProt accession | P11413 |
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| Gene | G6PD |
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| Organism | Homo sapiens |
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| Length | 515 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (9)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (120)
Diseases linked to this target (Open Targets).
- anemia, nonspherocytic hemolytic, due to G6PD deficiency · score 0.84
- anemia (phenotype) · score 0.75
- glucosephosphate dehydrogenase deficiency · score 0.65
- HbA1c measurement · score 0.62
- genetic disorder · score 0.53
- Barth syndrome · score 0.34
- metachromatic leukodystrophy · score 0.34
- Niemann-Pick disease type C · score 0.34
- Congenital hemolytic anemia · score 0.27
- familial hemolytic anemia · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P11413-F1 | alphafold | PREDICTED | 94.40 | — |
Amino-acid sequence (515 residues)
MAEQVALSRT QVCGILREEL FQGDAFHQSD THIFIIMGAS GDLAKKKIYP TIWWLFRDGL LPENTFIVGY ARSRLTVADI RKQSEPFFKA TPEEKLKLED FFARNSYVAG QYDDAASYQR LNSHMNALHL GSQANRLFYL ALPPTVYEAV TKNIHESCMS QIGWNRIIVE KPFGRDLQSS DRLSNHISSL FREDQIYRID HYLGKEMVQN LMVLRFANRI FGPIWNRDNI ACVILTFKEP FGTEGRGGYF DEFGIIRDVM QNHLLQMLCL VAMEKPASTN SDDVRDEKVK VLKCISEVQA NNVVLGQYVG NPDGEGEATK GYLDDPTVPR GSTTATFAAV VLYVENERWD GVPFILRCGK ALNERKAEVR LQFHDVAGDI FHQQCKRNEL VIRVQPNEAV YTKMMTKKPG MFFNPEESEL DLTYGNRYKN VKLPDAYERL ILDVFCGSQM HFVRSDELRE AWRIFTPLLH QIELEKPKPI PYIYGSRGPT EADELMKRVG FQYEGTYKWV NPHKL
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