Cefradine

ANTIINFECTIVES FOR SYSTEMIC USE

Key facts

Cefradine is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1974. DrugCentral lists 4 molecular targets, including MMP9, SSTR4 and pbpA. Recorded indications include Acute otitis media, Bacterial infection due to Klebsiella pneumoniae, Enterococcus Prostatitis and Enterococcus Urinary Tract Infection.

• Approval status: ofm (first approved 1974 by the FDA).
• Molecular targets: MMP9, SSTR4, pbpA and mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB (4 listed in DrugCentral).
• Indications: Acute otitis media, Bacterial infection due to Klebsiella pneumoniae, Enterococcus Prostatitis, Enterococcus Urinary Tract Infection and Escherichia coli urinary tract infection and others.
• ATC code: J01DB09 (First-generation cephalosporins).
• Molecular formula: C16H19N3O4S; molecular weight 349.41 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (29)

• Acute otitis media
• Bacterial infection due to Klebsiella pneumoniae
• Enterococcus Prostatitis
• Enterococcus Urinary Tract Infection
• Escherichia coli urinary tract infection
• Haemophilus Influenzae Acute Otitis Media
• Haemophilus influenzae pneumonia
• Infection due to Staphylococcus aureus
• Infection of bone
• Infection of skin AND/OR subcutaneous tissue
• Infectious disorder of joint
• Infective otitis media
• Klebsiella cystitis
• Klebsiella Prostatitis
• Lower respiratory tract infection
• Pharyngitis
• Pneumonia
• Pneumonia due to Streptococcus
• Prevention of Perioperative Infection
• Prostatitis
• Proteus Prostatitis
• Proteus urinary tract infection
• Staphylococcal pneumonia
• Staphylococcus Acute Otitis Media
• Streptococcal tonsillitis
• Streptococcus pyogenes infection
• Tonsillitis
• Upper respiratory infection
• Urinary tract infectious disease

Contraindications (2)

• Acute nephropathy
• Pseudomembranous enterocolitis

Mechanism & targets

Molecular targets (4)

Target	Gene	Action	Activity
Matrix metalloproteinase-9	MMP9	unknown	IC50 5.40
Somatostatin receptor type 4	SSTR4	unknown	IC50 4.30
Penicillin-binding protein 1A	pbpA	unknown	—
Bacterial penicillin-binding protein	mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1974-08-19	FDA	—	APOTHECON

ATC classification

ATC code	Therapeutic hierarchy
J01DB09	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER BETA-LACTAM ANTIBACTERIALS › First-generation cephalosporins

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Foetal monitoring abnormal	90.8
Incubator therapy	89.2
Developmental delay	65.8
Foetal arrhythmia	64.4
Uterine hypertonus	59.3
Feeling guilty	56.4
Consciousness fluctuating	56.1
Asthenopia	51.2

Chemical structure

• Molecular formula: C₁₆H₁₉N₃O₄S
• Molecular weight: 349.41 g/mol
• CAS number: 38821-53-3
• InChIKey: RDLPVSKMFDYCOR-UEKVPHQBSA-N
• PubChem CID: 38103

CC1=C(N2[C@H](SC1)[C@H](NC(=O)[C@H](N)C1=CCC=CC1)C2=O)C(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Cefradine used for?

DrugCentral lists the following indications for Cefradine: Acute otitis media, Bacterial infection due to Klebsiella pneumoniae, Enterococcus Prostatitis, Enterococcus Urinary Tract Infection, Escherichia coli urinary tract infection, Haemophilus Influenzae Acute Otitis Media, Haemophilus influenzae pneumonia and Infection due to Staphylococcus aureus and others.

How does Cefradine work?

Its molecular targets in DrugCentral include MMP9, SSTR4, pbpA and mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB (inhibitor).

When was Cefradine first approved?

Cefradine was first approved by the FDA in 1974.

What is the chemical formula of Cefradine?

Cefradine has the molecular formula C16H19N3O4S and a molecular weight of 349.41 g/mol.

Sources

• DrugCentral drug card 576 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1604 — compound record and bioactivity
• PubChem CID 38103 — chemical identifiers
• DrugBank DB01333 — drug record
• FDA UNII F1BC02I72W — substance identity
• DailyMed: FDA labels for Cefradine — current prescribing information (label search)
• UniProt P14780 (MMP9) — target protein
• UniProt P31391 (SSTR4) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.