Cefadroxil

ANTIINFECTIVES FOR SYSTEMIC USE

Key facts

Cefadroxil is an ofp drug catalogued in DrugCentral. It was first approved by the FDA in 1978. DrugCentral lists 2 molecular targets, including SLC15A1 and mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB. Recorded indications include Escherichia coli urinary tract infection, Infection due to Staphylococcus aureus, Infection of skin AND/OR subcutaneous tissue and Klebsiella cystitis.

• Approval status: ofp (first approved 1978 by the FDA).
• Molecular targets: SLC15A1 and mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB (2 listed in DrugCentral).
• Indications: Escherichia coli urinary tract infection, Infection due to Staphylococcus aureus, Infection of skin AND/OR subcutaneous tissue, Klebsiella cystitis and Proteus urinary tract infection and others.
• ATC code: J01DB05 (First-generation cephalosporins).
• Molecular formula: C16H17N3O5S; molecular weight 363.39 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (9)

• Escherichia coli urinary tract infection
• Infection due to Staphylococcus aureus
• Infection of skin AND/OR subcutaneous tissue
• Klebsiella cystitis
• Proteus urinary tract infection
• Streptococcal tonsillitis
• Streptococcus pyogenes infection
• Tonsillitis
• Urinary tract infectious disease

Off-label uses (1)

• Prevention of Bacterial Endocarditis

Contraindications (2)

• Impaired renal function disorder
• Pseudomembranous enterocolitis

Mechanism & targets

Molecular targets (2)

Target	Gene	Action	Activity
Solute carrier family 15 member 1	SLC15A1	unknown	Ki 2.14
Bacterial penicillin-binding protein	mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1978-02-17	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
J01DB05	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER BETA-LACTAM ANTIBACTERIALS › First-generation cephalosporins

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Nasal oedema	1054.1
Respiratory tract infection	524.6
Cross sensitivity reaction	466.8
Oedema	444.5
Asthma	426.4
Drug hypersensitivity	402.3
Chest pain	292.9
Wheezing	273.3
Type IV hypersensitivity reaction	225.2
Cough	223.7
Pain	199.1
Malaise	185.9

Chemical structure

• Molecular formula: C₁₆H₁₇N₃O₅S
• Molecular weight: 363.39 g/mol
• CAS number: —
• InChIKey: BOEGTKLJZSQCCD-UEKVPHQBSA-N
• PubChem CID: 47965

CC1=C(N2[C@H](SC1)[C@H](NC(=O)[C@H](N)C1=CC=C(O)C=C1)C2=O)C(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Cefadroxil used for?

DrugCentral lists the following indications for Cefadroxil: Escherichia coli urinary tract infection, Infection due to Staphylococcus aureus, Infection of skin AND/OR subcutaneous tissue, Klebsiella cystitis, Proteus urinary tract infection, Streptococcal tonsillitis, Streptococcus pyogenes infection and Tonsillitis and others.

How does Cefadroxil work?

Its molecular targets in DrugCentral include SLC15A1 and mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB (inhibitor).

When was Cefadroxil first approved?

Cefadroxil was first approved by the FDA in 1978.

What is the chemical formula of Cefadroxil?

Cefadroxil has the molecular formula C16H17N3O5S and a molecular weight of 363.39 g/mol.

Sources

• DrugCentral drug card 526 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1644 — compound record and bioactivity
• PubChem CID 47965 — chemical identifiers
• DrugBank DB01140 — drug record
• FDA UNII 280111G160 — substance identity
• DailyMed: FDA labels for Cefadroxil — current prescribing information (label search)
• UniProt P46059 (SLC15A1) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.