Cefazolin

Cephalosporin Antibacterial — ANTIINFECTIVES FOR SYSTEMIC USE

Key facts

Cefazolin is an ofp drug in the Cephalosporin Antibacterial class catalogued in DrugCentral. It was first approved by the FDA in 1973. DrugCentral lists 2 molecular targets, including pbpA and mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB. Recorded indications include Bacterial endocarditis, Bacterial pneumonia, Bacterial septicemia and Bacterial urinary infection.

• Approval status: ofp (first approved 1973 by the FDA).
• Drug class: Cephalosporin Antibacterial.
• Molecular targets: pbpA and mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB (2 listed in DrugCentral).
• Indications: Bacterial endocarditis, Bacterial pneumonia, Bacterial septicemia, Bacterial urinary infection and Cholangitis and others.
• ATC code: J01DB04 (First-generation cephalosporins).
• Molecular formula: C14H14N8O4S3; molecular weight 454.52 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (14)

• Bacterial endocarditis
• Bacterial pneumonia
• Bacterial septicemia
• Bacterial urinary infection
• Cholangitis
• Genitourinary Tract Infections
• Infection of biliary tract
• Infection of bone
• Infection of skin AND/OR subcutaneous tissue
• Infectious disorder of joint
• Lower respiratory tract infection
• Pneumonia due to Streptococcus
• Prevention of Perioperative Infection
• Staphylococcal pneumonia

Off-label uses (1)

• Prevention of Bacterial Endocarditis

Contraindications (4)

• Acute nephropathy
• Blood coagulation disorder
• Factor II deficiency
• Pseudomembranous enterocolitis

Mechanism & targets

• Established pharmacologic class: Cephalosporin Antibacterial

Molecular targets (2)

Target	Gene	Action	Activity
Penicillin-binding protein 1A	pbpA	unknown	—
Bacterial penicillin-binding protein	mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1973-10-04	FDA	—	GLAXOSMITHKLINE

ATC classification

ATC code	Therapeutic hierarchy
J01DB04	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER BETA-LACTAM ANTIBACTERIALS › First-generation cephalosporins

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Anaphylactic shock	1743.5
Anaphylactic reaction	1124.3
Hypotension	443.7
Acute generalised exanthematous pustulosis	393.7
Hypoprothrombinaemia	281.1
Drug reaction with eosinophilia and systemic symptoms	240.3
Bronchospasm	229.9
Lymphoid tissue hypoplasia	219.0
Clostridium test positive	218.6
Thymus hypoplasia	212.5
Fatigue	206.9
Cardiac arrest	202.1

Chemical structure

• Molecular formula: C₁₄H₁₄N₈O₄S₃
• Molecular weight: 454.52 g/mol
• CAS number: —
• InChIKey: MLYYVTUWGNIJIB-BXKDBHETSA-N
• PubChem CID: 33255

CC1=NN=C(SCC2=C(N3[C@H](SC2)[C@H](NC(=O)CN2C=NN=N2)C3=O)C(O)=O)S1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Cefazolin used for?

DrugCentral lists the following indications for Cefazolin: Bacterial endocarditis, Bacterial pneumonia, Bacterial septicemia, Bacterial urinary infection, Cholangitis, Genitourinary Tract Infections, Infection of biliary tract and Infection of bone and others.

How does Cefazolin work?

Its molecular targets in DrugCentral include pbpA and mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB (inhibitor).

When was Cefazolin first approved?

Cefazolin was first approved by the FDA in 1973.

What drug class does Cefazolin belong to?

Cefazolin is in the Cephalosporin Antibacterial class.

What is the chemical formula of Cefazolin?

Cefazolin has the molecular formula C14H14N8O4S3 and a molecular weight of 454.52 g/mol.

Sources

• DrugCentral drug card 530 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200523 — compound record and bioactivity
• PubChem CID 33255 — chemical identifiers
• DrugBank DB01327 — drug record
• FDA UNII IHS69L0Y4T — substance identity
• DailyMed: FDA labels for Cefazolin — current prescribing information (label search)
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.