Cytochrome P450 3A5 (CYP3A5)

About Cytochrome P450 3A5

Cytochrome P450 3A5 (CYP3A5) is a protein from Homo sapiens identified by UniProt accession P20815, 502 residues long. MolForge cross-references it against 0 known binders and 315 disease associations.

Target properties

Protein name	Cytochrome P450 3A5
UniProt accession	P20815
Gene	CYP3A5
Organism	Homo sapiens
Length	502 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (8)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (315)

Diseases linked to this target (Open Targets).

HIV infection · score 0.61
HIV-1 infection · score 0.60
COVID-19 · score 0.59
AIDS · score 0.58
chronic hepatitis C virus infection · score 0.57
infection · score 0.56
hepatitis C virus infection · score 0.55
HIV-Associated Lipodystrophy Syndrome · score 0.46
coronavirus infectious disease · score 0.43
cancer · score 0.41

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P20815-F1	alphafold	PREDICTED	93.41	—

Amino-acid sequence (502 residues)

MDLIPNLAVE TWLLLAVSLV LLYLYGTRTH GLFKRLGIPG PTPLPLLGNV LSYRQGLWKF DTECYKKYGK MWGTYEGQLP VLAITDPDVI RTVLVKECYS VFTNRRSLGP VGFMKSAISL AEDEEWKRIR SLLSPTFTSG KLKEMFPIIA QYGDVLVRNL RREAEKGKPV TLKDIFGAYS MDVITGTSFG VNIDSLNNPQ DPFVESTKKF LKFGFLDPLF LSIILFPFLT PVFEALNVSL FPKDTINFLS KSVNRMKKSR LNDKQKHRLD FLQLMIDSQN SKETESHKAL SDLELAAQSI IFIFAGYETT SSVLSFTLYE LATHPDVQQK LQKEIDAVLP NKAPPTYDAV VQMEYLDMVV NETLRLFPVA IRLERTCKKD VEINGVFIPK GSMVVIPTYA LHHDPKYWTE PEEFRPERFS KKKDSIDPYI YTPFGTGPRN CIGMRFALMN MKLALIRVLQ NFSFKPCKET QIPLKLDTQG LLQPEKPIVL KVDSRDGTLS GE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards