Histamine H2 receptor (HRH2)

About Histamine H2 receptor

Histamine H2 receptor (HRH2) is a protein from Homo sapiens identified by UniProt accession P25021, 359 residues long. MolForge cross-references it against 0 known binders and 292 disease associations.

Target properties

Protein name	Histamine H2 receptor
UniProt accession	P25021
Gene	HRH2
Organism	Homo sapiens
Length	359 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (292)

Diseases linked to this target (Open Targets).

gastroesophageal reflux disease · score 0.58
duodenal ulcer · score 0.58
Peptic ulcer · score 0.58
gastric ulcer · score 0.57
ulcer disease · score 0.55
COVID-19 · score 0.53
Esophagitis · score 0.51
dyspepsia · score 0.50
schizophrenia · score 0.49
HIV infection · score 0.48

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P25021-F1	alphafold	PREDICTED	82.95	—

Amino-acid sequence (359 residues)

MAPNGTASSF CLDSTACKIT ITVVLAVLIL ITVAGNVVVC LAVGLNRRLR NLTNCFIVSL AITDLLLGLL VLPFSAIYQL SCKWSFGKVF CNIYTSLDVM LCTASILNLF MISLDRYCAV MDPLRYPVLV TPVRVAISLV LIWVISITLS FLSIHLGWNS RNETSKGNHT TSKCKVQVNE VYGLVDGLVT FYLPLLIMCI TYYRIFKVAR DQAKRINHIS SWKAATIREH KATVTLAAVM GAFIICWFPY FTAFVYRGLR GDDAINEVLE AIVLWLGYAN SALNPILYAA LNRDFRTGYQ QLFCCRLANR NSHKTSLRSN ASQLSRTQSR EPRQQEEKPL KLQVWSGTEV TAPQGATDR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards