Substance-P receptor (TACR1)

About Substance-P receptor

Substance-P receptor (TACR1) is a protein from Homo sapiens identified by UniProt accession P25103, 407 residues long. MolForge cross-references it against 0 known binders and 426 disease associations.

Target properties

Protein name	Substance-P receptor
UniProt accession	P25103
Gene	TACR1
Organism	Homo sapiens
Length	407 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (426)

Diseases linked to this target (Open Targets).

Chemotherapy-induced nausea and vomiting · score 0.60
cancer · score 0.59
post operative nausea and vomiting · score 0.59
Nausea and vomiting · score 0.57
Vomiting · score 0.57
Nausea · score 0.55
ovarian cancer · score 0.53
neoplasm · score 0.52
lymphoma · score 0.46
leukemia · score 0.46

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P25103-F1	alphafold	PREDICTED	78.40	—

Amino-acid sequence (407 residues)

MDNVLPVDSD LSPNISTNTS EPNQFVQPAW QIVLWAAAYT VIVVTSVVGN VVVMWIILAH KRMRTVTNYF LVNLAFAEAS MAAFNTVVNF TYAVHNEWYY GLFYCKFHNF FPIAAVFASI YSMTAVAFDR YMAIIHPLQP RLSATATKVV ICVIWVLALL LAFPQGYYST TETMPSRVVC MIEWPEHPNK IYEKVYHICV TVLIYFLPLL VIGYAYTVVG ITLWASEIPG DSSDRYHEQV SAKRKVVKMM IVVVCTFAIC WLPFHIFFLL PYINPDLYLK KFIQQVYLAI MWLAMSSTMY NPIIYCCLND RFRLGFKHAF RCCPFISAGD YEGLEMKSTR YLQTQGSVYK VSRLETTIST VVGAHEEEPE DGPKATPSSL DLTSNCSSRS DSKTMTESFS FSSNVLS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards