Tradipitant

Drug profile

Key facts

Tradipitant is an onp drug catalogued in DrugCentral. It was first approved by the FDA in 2025. DrugCentral lists 1 molecular target, including TACR1. Recorded indications include Prevention of vomiting induced by motion.

• Approval status: onp (first approved 2025 by the FDA).
• Molecular targets: TACR1 (1 listed in DrugCentral).
• Indications: Prevention of vomiting induced by motion.
• Molecular formula: C28H16ClF6N5O; molecular weight 587.91 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Prevention of vomiting induced by motion

Mechanism & targets

Molecular targets (1)

Target	Gene	Action	Activity
Substance-P receptor	TACR1	inhibitor	Ki 10.62

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2025-12-30	FDA	—	Vanda Pharmaceuticals

Chemical structure

• Molecular formula: C₂₈H₁₆ClF₆N₅O
• Molecular weight: 587.91 g/mol
• CAS number: —
• InChIKey: CAVRKWRKTNINFF-UHFFFAOYSA-N
• PubChem CID: 9916461

C1=CC=C(C(=C1)C(=O)C2=C(N=CC=C2)C3=C(N(N=N3)CC4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F)C5=CC=NC=C5)Cl

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Tradipitant used for?

DrugCentral lists the following indications for Tradipitant: Prevention of vomiting induced by motion.

How does Tradipitant work?

Its molecular targets in DrugCentral include TACR1 (inhibitor).

When was Tradipitant first approved?

Tradipitant was first approved by the FDA in 2025.

What is the chemical formula of Tradipitant?

Tradipitant has the molecular formula C28H16ClF6N5O and a molecular weight of 587.91 g/mol.

Sources

• DrugCentral drug card 5803 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL3544984 — compound record and bioactivity
• PubChem CID 9916461 — chemical identifiers
• DrugBank DB12580 — drug record
• FDA UNII NY0COC51FI — substance identity
• DailyMed: FDA labels for Tradipitant — current prescribing information (label search)
• UniProt P25103 (TACR1) — target protein

How this page is built: methodology · editorial policy & corrections.