About 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (CYP8B1) is a protein
from Homo sapiens identified by UniProt accession
Q9UNU6, 501 residues long.
MolForge cross-references it against 0 known binders and
152 disease associations.
Target properties
| Protein name | 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase |
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| UniProt accession | Q9UNU6 |
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| Gene | CYP8B1 |
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| Organism | Homo sapiens |
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| Length | 501 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (8)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (152)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.37
- neurodegenerative disease · score 0.37
- eosinophil count · score 0.36
- leukocyte count · score 0.35
- monocyte percentage of leukocytes · score 0.34
- neutrophil count · score 0.33
- myeloid white cell count · score 0.33
- eosinophil percentage of leukocytes · score 0.32
- CCL17 measurement · score 0.30
- CCL2 measurement · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UNU6-F1 | alphafold | PREDICTED | 91.34 | — |
Amino-acid sequence (501 residues)
MVLWGPVLGA LLVVIAGYLC LPGMLRQRRP WEPPLDKGTV PWLGHAMAFR KNMFEFLKRM RTKHGDVFTV QLGGQYFTFV MDPLSFGSIL KDTQRKLDFG QYAKKLVLKV FGYRSVQGDH EMIHSASTKH LRGDGLKDLN ETMLDSLSFV MLTSKGWSLD ASCWHEDSLF RFCYYILFTA GYLSLFGYTK DKEQDLLQAG ELFMEFRKFD LLFPRFVYSL LWPREWLEVG RLQRLFHKML SVSHSQEKEG ISNWLGNMLQ FLREQGVPSA MQDKFNFMML WASQGNTGPT SFWALLYLLK HPEAIRAVRE EATQVLGEAR LETKQSFAFK LGALQHTPVL DSVVEETLRL RAAPTLLRLV HEDYTLKMSS GQEYLFRHGD ILALFPYLSV HMDPDIHPEP TVFKYDRFLN PNGSRKVDFF KTGKKIHHYT MPWGSGVSIC PGRFFALSEV KLFILLMVTH FDLELVDPDT PLPHVDPQRW GFGTMQPSHD VRFRYRLHPT E
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