Tioconazole

Azole Antifungal — DERMATOLOGICALS

Key facts

Tioconazole is an ofp drug in the Azole Antifungal class catalogued in DrugCentral. It was first approved by the FDA in 1983. DrugCentral lists 5 molecular targets, including CYP8B1, CYP17A1 and ATG4A. Recorded indications include Candidal vulvovaginitis.

• Approval status: ofp (first approved 1983 by the FDA).
• Drug class: Azole Antifungal.
• Molecular targets: CYP8B1, CYP17A1, ATG4A and ATG4B (5 listed in DrugCentral).
• Indications: Candidal vulvovaginitis.
• ATC code: D01AC07 (Imidazole and triazole derivatives).
• Molecular formula: C16H13Cl3N2OS; molecular weight 387.70 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Candidal vulvovaginitis

Mechanism & targets

• Established pharmacologic class: Azole Antifungal

Molecular targets (5)

Target	Gene	Action	Activity
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase	CYP8B1	inhibitor	Kd 6.68
Steroid 17-alpha-hydroxylase/17,20 lyase	CYP17A1	unknown	Ki 6.30
Cysteine protease ATG4A	ATG4A	unknown	IC50 5.89
Cysteine protease ATG4B	ATG4B	unknown	IC50 5.75
Lanosterol 14-alpha demethylase	ERG11	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1983-02-18	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
D01AC07	DERMATOLOGICALS › ANTIFUNGALS FOR DERMATOLOGICAL USE › ANTIFUNGALS FOR TOPICAL USE › Imidazole and triazole derivatives
G01AF08	GENITO URINARY SYSTEM AND SEX HORMONES › GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS › ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS › Imidazole derivatives

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Tioconazole is on its molecule page.

• Molecular formula: C₁₆H₁₃Cl₃N₂OS
• Molecular weight: 387.70 g/mol
• CAS number: 65899-73-2
• InChIKey: QXHHHPZILQDDPS-UHFFFAOYSA-N
• PubChem CID: 5482

ClC1=C(COC(CN2C=CN=C2)C2=C(Cl)C=C(Cl)C=C2)C=CS1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Tioconazole used for?

DrugCentral lists the following indications for Tioconazole: Candidal vulvovaginitis.

How does Tioconazole work?

Its molecular targets in DrugCentral include CYP8B1 (inhibitor), CYP17A1, ATG4A and ATG4B.

When was Tioconazole first approved?

Tioconazole was first approved by the FDA in 1983.

What drug class does Tioconazole belong to?

Tioconazole is in the Azole Antifungal class.

What is the chemical formula of Tioconazole?

Tioconazole has the molecular formula C16H13Cl3N2OS and a molecular weight of 387.70 g/mol.

Sources

• DrugCentral drug card 2675 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200438 — compound record and bioactivity
• PubChem CID 5482 — chemical identifiers
• DrugBank DB01007 — drug record
• FDA UNII S57Y5X1117 — substance identity
• DailyMed: FDA labels for Tioconazole — current prescribing information (label search)
• UniProt Q9UNU6 (CYP8B1) — target protein
• UniProt P05093 (CYP17A1) — target protein
• UniProt Q8WYN0 (ATG4A) — target protein
• UniProt Q9Y4P1 (ATG4B) — target protein

How this page is built: methodology · editorial policy & corrections.