About Cysteine protease ATG4A
Cysteine protease ATG4A (ATG4A) is a protein
from Homo sapiens identified by UniProt accession
Q8WYN0, 398 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Cysteine protease ATG4A |
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| UniProt accession | Q8WYN0 |
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| Gene | ATG4A |
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| Organism | Homo sapiens |
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| Length | 398 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (35)
Diseases linked to this target (Open Targets).
- X-linked Alport syndrome · score 0.26
- breast adenocarcinoma · score 0.18
- pancreatic adenocarcinoma · score 0.10
- neoplasm · score 0.05
- ghosal hematodiaphyseal dysplasia · score 0.03
- chronic myeloproliferative disorder · score 0.03
- neutropenia, severe congenital, 1, autosomal dominant · score 0.03
- Granuloma · score 0.02
- cancer · score 0.02
- infection · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WYN0-F1 | alphafold | PREDICTED | 84.86 | — |
Amino-acid sequence (398 residues)
MESVLSKYED QITIFTDYLE EYPDTDELVW ILGKQHLLKT EKSKLLSDIS ARLWFTYRRK FSPIGGTGPS SDAGWGCMLR CGQMMLAQAL ICRHLGRDWS WEKQKEQPKE YQRILQCFLD RKDCCYSIHQ MAQMGVGEGK SIGEWFGPNT VAQVLKKLAL FDEWNSLAVY VSMDNTVVIE DIKKMCRVLP LSADTAGDRP PDSLTASNQS KGTSAYCSAW KPLLLIVPLR LGINQINPVY VDAFKECFKM PQSLGALGGK PNNAYYFIGF LGDELIFLDP HTTQTFVDTE ENGTVNDQTF HCLQSPQRMN ILNLDPSVAL GFFCKEEKDF DNWCSLVQKE ILKENLRMFE LVQKHPSHWP PFVPPAKPEV TTTGAEFIDS TEQLEEFDLE EDFEILSV
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