About Steroid 17-alpha-hydroxylase/17,20 lyase
Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1) is a protein
from Homo sapiens identified by UniProt accession
P05093, 508 residues long.
MolForge cross-references it against 0 known binders and
401 disease associations.
Target properties
| Protein name | Steroid 17-alpha-hydroxylase/17,20 lyase |
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| UniProt accession | P05093 |
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| Gene | CYP17A1 |
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| Organism | Homo sapiens |
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| Length | 508 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (9)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (401)
Diseases linked to this target (Open Targets).
- congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency · score 0.80
- 46,XY disorder of sex development due to isolated 17,20 lyase deficiency · score 0.67
- congenital adrenal hyperplasia · score 0.63
- 17,20-lyase deficiency, isolated · score 0.61
- adrenal gland disease · score 0.60
- prostate cancer · score 0.59
- 17-alpha-hydroxylase/17,20-lyase deficiency, combined complete · score 0.53
- 17-alpha-hydroxylase/17,20-lyase deficiency, combined partial · score 0.52
- metastatic prostate cancer · score 0.51
- prostate carcinoma · score 0.50
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P05093-F1 | alphafold | PREDICTED | 91.77 | — |
Amino-acid sequence (508 residues)
MWELVALLLL TLAYLFWPKR RCPGAKYPKS LLSLPLVGSL PFLPRHGHMH NNFFKLQKKY GPIYSVRMGT KTTVIVGHHQ LAKEVLIKKG KDFSGRPQMA TLDIASNNRK GIAFADSGAH WQLHRRLAMA TFALFKDGDQ KLEKIICQEI STLCDMLATH NGQSIDISFP VFVAVTNVIS LICFNTSYKN GDPELNVIQN YNEGIIDNLS KDSLVDLVPW LKIFPNKTLE KLKSHVKIRN DLLNKILENY KEKFRSDSIT NMLDTLMQAK MNSDNGNAGP DQDSELLSDN HILTTIGDIF GAGVETTTSV VKWTLAFLLH NPQVKKKLYE EIDQNVGFSR TPTISDRNRL LLLEATIREV LRLRPVAPML IPHKANVDSS IGEFAVDKGT EVIINLWALH HNEKEWHQPD QFMPERFLNP AGTQLISPSV SYLPFGAGPR SCIGEILARQ ELFLIMAWLL QRFDLEVPDD GQLPSLEGIP KVVFLIDSFK VKIKVRQAWR EAQAEGST
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