About Lanosterol 14-alpha demethylase
Lanosterol 14-alpha demethylase (CYP51A1) is a protein
from Homo sapiens identified by UniProt accession
Q16850, 509 residues long.
MolForge cross-references it against 0 known binders and
395 disease associations.
Target properties
| Protein name | Lanosterol 14-alpha demethylase |
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| UniProt accession | Q16850 |
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| Gene | CYP51A1 |
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| Organism | Homo sapiens |
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| Length | 509 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (12)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (395)
Diseases linked to this target (Open Targets).
- Developmental cataract · score 0.40
- Prolonged QT interval · score 0.34
- hematocrit · score 0.29
- neurodegenerative disease · score 0.28
- hemoglobin measurement · score 0.25
- eosinophil count · score 0.23
- erythrocyte count · score 0.23
- long QT syndrome 11 · score 0.20
- Abnormality of the cardiovascular system · score 0.19
- familial long QT syndrome · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16850-F1 | alphafold | PREDICTED | 90.44 | — |
Amino-acid sequence (509 residues)
MAAAAGMLLL GLLQAGGSVL GQAMEKVTGG NLLSMLLIAC AFTLSLVYLI RLAAGHLVQL PAGVKSPPYI FSPIPFLGHA IAFGKSPIEF LENAYEKYGP VFSFTMVGKT FTYLLGSDAA ALLFNSKNED LNAEDVYSRL TTPVFGKGVA YDVPNPVFLE QKKMLKSGLN IAHFKQHVSI IEKETKEYFE SWGESGEKNV FEALSELIIL TASHCLHGKE IRSQLNEKVA QLYADLDGGF SHAAWLLPGW LPLPSFRRRD RAHREIKDIF YKAIQKRRQS QEKIDDILQT LLDATYKDGR PLTDDEVAGM LIGLLLAGQH TSSTTSAWMG FFLARDKTLQ KKCYLEQKTV CGENLPPLTY DQLKDLNLLD RCIKETLRLR PPIMIMMRMA RTPQTVAGYT IPPGHQVCVS PTVNQRLKDS WVERLDFNPD RYLQDNPASG EKFAYVPFGA GRHRCIGENF AYVQIKTIWS TMLRLYEFDL IDGYFPTVNY TTMIHTPENP VIRYKRRSK
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