About Amyloid-beta precursor protein
Amyloid-beta precursor protein (APP) is a protein
from Homo sapiens identified by UniProt accession
P05067, 770 residues long.
MolForge cross-references it against 0 known binders and
947 disease associations.
Target properties
| Protein name | Amyloid-beta precursor protein |
|---|
| UniProt accession | P05067 |
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| Gene | APP |
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| Organism | Homo sapiens |
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| Length | 770 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (947)
Diseases linked to this target (Open Targets).
- Alzheimer disease type 1 · score 0.79
- Alzheimer disease · score 0.75
- cerebral amyloid angiopathy, APP-related · score 0.73
- Hereditary cerebral hemorrhage with amyloidosis · score 0.66
- Hereditary cerebral hemorrhage with amyloidosis, Dutch type · score 0.62
- Hereditary cerebral hemorrhage with amyloidosis, Iowa type · score 0.62
- Hereditary cerebral hemorrhage with amyloidosis, Flemish type · score 0.62
- Hereditary cerebral hemorrhage with amyloidosis, Italian type · score 0.62
- Hereditary cerebral hemorrhage with amyloidosis, Piedmont type · score 0.62
- Hereditary cerebral hemorrhage with amyloidosis, Arctic type · score 0.62
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P05067-F1 | alphafold | PREDICTED | 67.39 | — |
Amino-acid sequence (770 residues)
MLPGLALLLL AAWTARALEV PTDGNAGLLA EPQIAMFCGR LNMHMNVQNG KWDSDPSGTK TCIDTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR GRKQCKTHPH FVIPYRCLVG EFVSDALLVP DKCKFLHQER MDVCETHLHW HTVAKETCSE KSTNLHDYGM LLPCGIDKFR GVEFVCCPLA EESDNVDSAD AEEDDSDVWW GGADTDYADG SEDKVVEVAE EEEVAEVEEE EADDDEDDED GDEVEEEAEE PYEEATERTT SIATTTTTTT ESVEEVVREV CSEQAETGPC RAMISRWYFD VTEGKCAPFF YGGCGGNRNN FDTEEYCMAV CGSAMSQSLL KTTQEPLARD PVKLPTTAAS TPDAVDKYLE TPGDENEHAH FQKAKERLEA KHRERMSQVM REWEEAERQA KNLPKADKKA VIQHFQEKVE SLEQEAANER QQLVETHMAR VEAMLNDRRR LALENYITAL QAVPPRPRHV FNMLKKYVRA EQKDRQHTLK HFEHVRMVDP KKAAQIRSQV MTHLRVIYER MNQSLSLLYN VPAVAEEIQD EVDELLQKEQ NYSDDVLANM ISEPRISYGN DALMPSLTET KTTVELLPVN GEFSLDDLQP WHSFGADSVP ANTENEVEPV DARPAADRGL TTRPGSGLTN IKTEEISEVK MDAEFRHDSG YEVHHQKLVF FAEDVGSNKG AIIGLMVGGV VIATVIVITL VMLKKKQYTS IHHGVVEVDA AVTPEERHLS KMQQNGYENP TYKFFEQMQN
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