Retinol

Vitamin A — ALIMENTARY TRACT AND METABOLISM

Key facts

Retinol is an ofp drug in the Vitamin A class catalogued in DrugCentral. It was first approved by the FDA in 1953. DrugCentral lists 16 molecular targets, including LGB, APP and RBP4. Recorded indications include Mineral deficiency, Mineral Deficiency Prevention, Prevention of dental caries and Vitamin A deficiency.

• Approval status: ofp (first approved 1953 by the FDA).
• Drug class: Vitamin A.
• Molecular targets: LGB, APP, RBP4 and SNCA (16 listed in DrugCentral).
• Indications: Mineral deficiency, Mineral Deficiency Prevention, Prevention of dental caries, Vitamin A deficiency and Vitamin deficiency and others.
• ATC code: A11CA01 (Vitamin A, plain).
• Molecular formula: C20H30O; molecular weight 286.46 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (6)

• Mineral deficiency
• Mineral Deficiency Prevention
• Prevention of dental caries
• Vitamin A deficiency
• Vitamin deficiency
• Vitamin Deficiency Prevention

Off-label uses (3)

• Abetalipoproteinemia
• Diaper rash
• Skin irritation

Contraindications (22)

• Anemia due to enzyme deficiency
• Arteriosclerosis obliterans
• Disease of liver
• Diverticular disease
• Gastroenteritis
• Hb SS disease
• Hemochromatosis
• Hemolytic anemia
• Hemosiderosis
• Hypercalcemia
• Hyperphosphatemia
• Hypervitaminosis A
• Hypervitaminosis D
• Kidney disease
• Kidney stone
• Malabsorption States
• Peptic ulcer
• Pregnancy, function
• Primary hyperoxaluria
• Repeated Blood Transfusions
• Sarcoidosis
• Ulcerative colitis

Mechanism & targets

• Established pharmacologic class: Vitamin A

Molecular targets (16)

Target	Gene	Action	Activity
Beta-lactoglobulin	LGB	unknown	Kd 7.44
Amyloid beta A4 protein	APP	unknown	IC50 6.75
Retinol-binding protein 4	RBP4	unknown	Kd 6.74
Alpha-synuclein	SNCA	unknown	IC50 6.72
Nuclear receptor subfamily 2 group C member 2	NR2C2	agonist	EC50 4.71
Retinoid-binding protein 7	RBP7	unknown	—
Retinol-binding protein 2	RBP2	unknown	—
11-cis retinol dehydrogenase	RDH5	unknown	—
Retinal dehydrogenase 1	ALDH1A1	unknown	—
Retinaldehyde-binding protein 1	RLBP1	unknown	—
Retinol-binding protein 1	RBP1	unknown	—
Retinal dehydrogenase 2	ALDH1A2	unknown	—
Retinol dehydrogenase 12	RDH12	unknown	—
Retinol dehydrogenase 13	RDH13	unknown	—
Retinol-binding protein 3	RBP3	unknown	—
Retinol-binding protein 5	RBP5	unknown	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1953-02-20	FDA	—	HOSPIRA

ATC classification

ATC code	Therapeutic hierarchy
A11CA01	ALIMENTARY TRACT AND METABOLISM › VITAMINS › VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO › Vitamin A, plain
D10AD02	DERMATOLOGICALS › ANTI-ACNE PREPARATIONS › ANTI-ACNE PREPARATIONS FOR TOPICAL USE › Retinoids for topical use in acne
R01AX02	RESPIRATORY SYSTEM › NASAL PREPARATIONS › DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE › Other nasal preparations
S01XA02	SENSORY ORGANS › OPHTHALMOLOGICALS › OTHER OPHTHALMOLOGICALS › Other ophthalmologicals

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Off label use	195.8
Toxicity to various agents	167.9
Completed suicide	152.2
Gastrooesophageal reflux disease	127.3
Drug ineffective	122.1
Drug abuse	110.3
Presbyacusis	101.3
Pleural thickening	100.6
Injection site reaction	100.1
Blood magnesium increased	97.6
Onychomadesis	94.7
Onychomycosis	94.2

Chemical structure

• Molecular formula: C₂₀H₃₀O
• Molecular weight: 286.46 g/mol
• CAS number: 68-26-8
• InChIKey: FPIPGXGPPPQFEQ-OVSJKPMPSA-N
• PubChem CID: 445354

C\C(=C/CO)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Retinol used for?

DrugCentral lists the following indications for Retinol: Mineral deficiency, Mineral Deficiency Prevention, Prevention of dental caries, Vitamin A deficiency, Vitamin deficiency and Vitamin Deficiency Prevention.

How does Retinol work?

Its molecular targets in DrugCentral include LGB, APP, RBP4 and SNCA.

When was Retinol first approved?

Retinol was first approved by the FDA in 1953.

What drug class does Retinol belong to?

Retinol is in the Vitamin A class.

What is the chemical formula of Retinol?

Retinol has the molecular formula C20H30O and a molecular weight of 286.46 g/mol.

Sources

• DrugCentral drug card 2831 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL986 — compound record and bioactivity
• PubChem CID 445354 — chemical identifiers
• DrugBank DB00162 — drug record
• FDA UNII G2SH0XKK91 — substance identity
• DailyMed: FDA labels for Retinol — current prescribing information (label search)
• UniProt P05067 (APP) — target protein
• UniProt P02753 (RBP4) — target protein
• UniProt P37840 (SNCA) — target protein
• UniProt P49116 (NR2C2) — target protein
• UniProt Q96R05 (RBP7) — target protein
• UniProt P50120 (RBP2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.