Retinaldehyde-binding protein 1 (RLBP1)

About Retinaldehyde-binding protein 1

Retinaldehyde-binding protein 1 (RLBP1) is a protein from Homo sapiens identified by UniProt accession P12271, 317 residues long. MolForge cross-references it against 0 known binders and 141 disease associations.

Target properties

Protein name	Retinaldehyde-binding protein 1
UniProt accession	P12271
Gene	RLBP1
Organism	Homo sapiens
Length	317 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (141)

Diseases linked to this target (Open Targets).

fundus albipunctatus · score 0.71
retinitis pigmentosa · score 0.67
Bothnia retinal dystrophy · score 0.66
Newfoundland cone-rod dystrophy · score 0.63
retinitis punctata albescens · score 0.63
Retinal dystrophy · score 0.52
Joubert syndrome and related disorders · score 0.48
autosomal recessive retinitis pigmentosa · score 0.46
Posterior column ataxia - retinitis pigmentosa · score 0.37
RLBP1-related retinopathy · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P12271-F1	alphafold	PREDICTED	91.52	—

Amino-acid sequence (317 residues)

MSEGVGTFRM VPEEEQELRA QLEQLTTKDH GPVFGPCSQL PRHTLQKAKD ELNEREETRE EAVRELQEMV QAQAASGEEL AVAVAERVQE KDSGFFLRFI RARKFNVGRA YELLRGYVNF RLQYPELFDS LSPEAVRCTI EAGYPGVLSS RDKYGRVVML FNIENWQSQE ITFDEILQAY CFILEKLLEN EETQINGFCI IENFKGFTMQ QAASLRTSDL RKMVDMLQDS FPARFKAIHF IHQPWYFTTT YNVVKPFLKS KLLERVFVHG DDLSGFYQEI DENILPSDFG GTLPKYDGKA VAEQLFGPQA QAENTAF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards