About Retinal dehydrogenase 2
Retinal dehydrogenase 2 (ALDH1A2) is a protein
from Homo sapiens identified by UniProt accession
O94788, 518 residues long.
MolForge cross-references it against 0 known binders and
274 disease associations.
Target properties
| Protein name | Retinal dehydrogenase 2 |
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| UniProt accession | O94788 |
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| Gene | ALDH1A2 |
|---|
| Organism | Homo sapiens |
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| Length | 518 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (274)
Diseases linked to this target (Open Targets).
- diaphragmatic hernia 4, with cardiovascular defects · score 0.60
- high density lipoprotein cholesterol measurement · score 0.51
- serum metabolite measurement · score 0.51
- triglyceride measurement · score 0.49
- total cholesterol measurement · score 0.48
- phosphatidylethanolamine measurement · score 0.48
- phosphatidylcholine measurement · score 0.48
- lymphocyte count · score 0.48
- vitamin D measurement · score 0.47
- alkaline phosphatase measurement · score 0.47
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94788-F1 | alphafold | PREDICTED | 95.78 | — |
Amino-acid sequence (518 residues)
MTSSKIEMPG EVKADPAALM ASLHLLPSPT PNLEIKYTKI FINNEWQNSE SGRVFPVYNP ATGEQVCEVQ EADKADIDKA VQAARLAFSL GSVWRRMDAS ERGRLLDKLA DLVERDRAVL ATMESLNGGK PFLQAFYVDL QGVIKTFRYY AGWADKIHGM TIPVDGDYFT FTRHEPIGVC GQIIPWNFPL LMFAWKIAPA LCCGNTVVIK PAEQTPLSAL YMGALIKEAG FPPGVINILP GYGPTAGAAI ASHIGIDKIA FTGSTEVGKL IQEAAGRSNL KRVTLELGGK SPNIIFADAD LDYAVEQAHQ GVFFNQGQCC TAGSRIFVEE SIYEEFVRRS VERAKRRVVG SPFDPTTEQG PQIDKKQYNK ILELIQSGVA EGAKLECGGK GLGRKGFFIE PTVFSNVTDD MRIAKEEIFG PVQEILRFKT MDEVIERANN SDFGLVAAVF TNDINKALTV SSAMQAGTVW INCYNALNAQ SPFGGFKMSG NGREMGEFGL REYSEVKTVT VKIPQKNS
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