About Nuclear receptor subfamily 2 group C member 2
Nuclear receptor subfamily 2 group C member 2 (NR2C2) is a protein
from Homo sapiens identified by UniProt accession
P49116, 596 residues long.
MolForge cross-references it against 0 known binders and
283 disease associations.
Target properties
| Protein name | Nuclear receptor subfamily 2 group C member 2 |
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| UniProt accession | P49116 |
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| Gene | NR2C2 |
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| Organism | Homo sapiens |
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| Length | 596 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (283)
Diseases linked to this target (Open Targets).
- bone density · score 0.11
- urate measurement · score 0.11
- MODY · score 0.11
- hypertension · score 0.10
- systolic blood pressure · score 0.10
- hepatocellular carcinoma · score 0.10
- urinary bladder carcinoma · score 0.09
- hemoglobin measurement · score 0.09
- diastolic blood pressure · score 0.09
- body height · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49116-F1 | alphafold | PREDICTED | 65.34 | — |
Amino-acid sequence (596 residues)
MTSPSPRIQI ISTDSAVASP QRIQIVTDQQ TGQKIQIVTA VDASGSPKQQ FILTSPDGAG TGKVILASPE TSSAKQLIFT TSDNLVPGRI QIVTDSASVE RLLGKTDVQR PQVVEYCVVC GDKASGRHYG AVSCEGCKGF FKRSVRKNLT YSCRSNQDCI INKHHRNRCQ FCRLKKCLEM GMKMESVQSE RKPFDVQREK PSNCAASTEK IYIRKDLRSP LIATPTFVAD KDGARQTGLL DPGMLVNIQQ PLIREDGTVL LATDSKAETS QGALGTLANV VTSLANLSES LNNGDTSEIQ PEDQSASEIT RAFDTLAKAL NTTDSSSSPS LADGIDTSGG GSIHVISRDQ STPIIEVEGP LLSDTHVTFK LTMPSPMPEY LNVHYICESA SRLLFLSMHW ARSIPAFQAL GQDCNTSLVR ACWNELFTLG LAQCAQVMSL STILAAIVNH LQNSIQEDKL SGDRIKQVME HIWKLQEFCN SMAKLDIDGY EYAYLKAIVL FSPDHPGLTS TSQIEKFQEK AQMELQDYVQ KTYSEDTYRL ARILVRLPAL RLMSSNITEE LFFTGLIGNV SIDSIIPYIL KMETAEYNGQ ITGASL
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