Retinol dehydrogenase 12 (RDH12)
Homo sapiens — UniProt Q96NR8
Data last refreshed: (UniProt release unknown)
Key facts
Retinol dehydrogenase 12 (RDH12) is a protein from Homo sapiens identified by UniProt accession Q96NR8, 316 residues long. MolForge cross-references it against 1 known binders and 105 disease associations.
- UniProt accession: Q96NR8; gene symbol RDH12.
- Organism: Homo sapiens.
- Length: 316 amino acids.
- Top disease associations (Open Targets): Leber congenital amaurosis, retinitis pigmentosa and Retinal dystrophy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Retinol dehydrogenase 12 |
|---|---|
| UniProt accession | Q96NR8 |
| Gene | RDH12 |
| Organism | Homo sapiens |
| Length | 316 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (105)
Diseases linked to this target (Open Targets).
- Leber congenital amaurosis · score 0.75
- retinitis pigmentosa · score 0.70
- Retinal dystrophy · score 0.56
- Macular dystrophy · score 0.49
- Cone rod dystrophy · score 0.48
- cone-rod dystrophy · score 0.45
- Posterior column ataxia - retinitis pigmentosa · score 0.42
- Abnormality of the eye · score 0.40
- neurodegenerative disease · score 0.28
- Stargardt disease · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96NR8-F1 | alphafold | PREDICTED | 92.41 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96NR8.
Amino-acid sequence (316 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RDH12?
The strongest Open Targets associations for RDH12 are Leber congenital amaurosis, retinitis pigmentosa, Retinal dystrophy, Macular dystrophy and Cone rod dystrophy.
How long is the RDH12 protein?
The Homo sapiens RDH12 protein (UniProt Q96NR8) is 316 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96NR8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96NR8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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