About Aldehyde dehydrogenase 1A1
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a protein
from Homo sapiens identified by UniProt accession
P00352, 501 residues long.
MolForge cross-references it against 0 known binders and
422 disease associations.
Target properties
| Protein name | Aldehyde dehydrogenase 1A1 |
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| UniProt accession | P00352 |
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| Gene | ALDH1A1 |
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| Organism | Homo sapiens |
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| Length | 501 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (422)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.17
- cutaneous melanoma · score 0.12
- neoplasm · score 0.12
- age at menarche · score 0.11
- urinary bladder cancer · score 0.11
- cancer · score 0.11
- melanoma · score 0.11
- acute myeloid leukemia · score 0.10
- non-small cell lung carcinoma · score 0.10
- breast cancer · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P00352-F1 | alphafold | PREDICTED | 97.80 | — |
Amino-acid sequence (501 residues)
MSSSGTPDLP VLLTDLKIQY TKIFINNEWH DSVSGKKFPV FNPATEEELC QVEEGDKEDV DKAVKAARQA FQIGSPWRTM DASERGRLLY KLADLIERDR LLLATMESMN GGKLYSNAYL NDLAGCIKTL RYCAGWADKI QGRTIPIDGN FFTYTRHEPI GVCGQIIPWN FPLVMLIWKI GPALSCGNTV VVKPAEQTPL TALHVASLIK EAGFPPGVVN IVPGYGPTAG AAISSHMDID KVAFTGSTEV GKLIKEAAGK SNLKRVTLEL GGKSPCIVLA DADLDNAVEF AHHGVFYHQG QCCIAASRIF VEESIYDEFV RRSVERAKKY ILGNPLTPGV TQGPQIDKEQ YDKILDLIES GKKEGAKLEC GGGPWGNKGY FVQPTVFSNV TDEMRIAKEE IFGPVQQIMK FKSLDDVIKR ANNTFYGLSA GVFTKDIDKA ITISSALQAG TVWVNCYGVV SAQCPFGGFK MSGNGRELGE YGFHEYTEVK TVTVKISQKN S
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