Diiodohydroxyquinoline

GENITO URINARY SYSTEM AND SEX HORMONES

Key facts

Diiodohydroxyquinoline is a drug catalogued in DrugCentral. DrugCentral lists 11 molecular targets, including MAPK1, MAPK14 and ADORA3. Recorded indications include Amebic infection.

• Molecular targets: MAPK1, MAPK14, ADORA3 and ACE (11 listed in DrugCentral).
• Indications: Amebic infection.
• ATC code: G01AC01 (Quinoline derivatives).
• Molecular formula: C9H5I2NO; molecular weight 396.95 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Amebic infection

Off-label uses (6)

• Atopic dermatitis
• Contact dermatitis
• Eruption of skin
• Lichen simplex chronicus
• Pruritus ani
• Pruritus of genital organs

Contraindications (7)

• Adrenal cortical hypofunction
• Atrophoderma
• Disease of liver
• Optic neuritis
• Peripheral nerve disease
• Peripheral vascular disease
• Telangiectasia disorder

Mechanism & targets

Molecular targets (11)

Target	Gene	Action	Activity
Mitogen-activated protein kinase 1	MAPK1	unknown	IC50 6.53
Mitogen-activated protein kinase 14	MAPK14	unknown	IC50 6.44
Adenosine receptor A3	ADORA3	unknown	Ki 6.28
Angiotensin-converting enzyme	ACE	unknown	IC50 6.04
Tyrosine-protein kinase Fyn	FYN	unknown	IC50 5.80
Epidermal growth factor receptor	EGFR	unknown	IC50 5.72
Tyrosine-protein kinase Lck	LCK	unknown	IC50 5.61
Beta-lactamase NDM-1	blaNDM-1	unknown	IC50 5.60
Mitogen-activated protein kinase 3	MAPK3	unknown	IC50 5.28
Catechol O-methyltransferase	Comt	unknown	IC50 5.25
Receptor tyrosine-protein kinase erbB-2	ERBB2	unknown	IC50 5.07

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
G01AC01	GENITO URINARY SYSTEM AND SEX HORMONES › GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS › ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS › Quinoline derivatives

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Diiodohydroxyquinoline is on its molecule page.

• Molecular formula: C₉H₅I₂NO
• Molecular weight: 396.95 g/mol
• CAS number: 83-73-8
• InChIKey: UXZFQZANDVDGMM-UHFFFAOYSA-N
• PubChem CID: 3728

OC1=C2N=CC=CC2=C(I)C=C1I

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Diiodohydroxyquinoline used for?

DrugCentral lists the following indications for Diiodohydroxyquinoline: Amebic infection.

How does Diiodohydroxyquinoline work?

Its molecular targets in DrugCentral include MAPK1, MAPK14, ADORA3 and ACE.

What is the chemical formula of Diiodohydroxyquinoline?

Diiodohydroxyquinoline has the molecular formula C9H5I2NO and a molecular weight of 396.95 g/mol.

Sources

• DrugCentral drug card 1457 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL86754 — compound record and bioactivity
• PubChem CID 3728 — chemical identifiers
• DrugBank DB09115 — drug record
• FDA UNII 63W7IE88K8 — substance identity
• DailyMed: FDA labels for Diiodohydroxyquinoline — current prescribing information (label search)
• UniProt P28482 (MAPK1) — target protein
• UniProt Q16539 (MAPK14) — target protein
• UniProt P0DMS8 (ADORA3) — target protein
• UniProt P06241 (FYN) — target protein
• UniProt P00533 (EGFR) — target protein
• UniProt P06239 (LCK) — target protein

How this page is built: methodology · editorial policy & corrections.