Dequalinium

DERMATOLOGICALS

Key facts

Dequalinium is a drug catalogued in DrugCentral. DrugCentral lists 7 molecular targets, including Kcnn3, Kcnn2 and CNGA1.

• Molecular targets: Kcnn3, Kcnn2, CNGA1 and KCNN1 (7 listed in DrugCentral).
• ATC code: D08AH01 (Quinoline derivatives).
• Molecular formula: C30H40N4; molecular weight 456.68 g/mol.

Mechanism & targets

Molecular targets (7)

Target	Gene	Action	Activity
Small conductance calcium-activated potassium channel protein 3	Kcnn3	unknown	Ki 6.85
Small conductance calcium-activated potassium channel protein 2	Kcnn2	blocker	IC50 6.80
cGMP-gated cation channel alpha-1	CNGA1	blocker	IC50 6.70
Small conductance calcium-activated potassium channel protein 1	KCNN1	blocker	IC50 6.40
Small conductance calcium-activated potassium channel protein 3	KCNN3	unknown	IC50 5.89
Cyclic nucleotide-gated olfactory channel	CNGA2	blocker	IC50 5.60
Protein kinase C alpha type	PRKCA	unknown	IC50 4.96

ATC classification

ATC code	Therapeutic hierarchy
D08AH01	DERMATOLOGICALS › ANTISEPTICS AND DISINFECTANTS › ANTISEPTICS AND DISINFECTANTS › Quinoline derivatives
G01AC05	GENITO URINARY SYSTEM AND SEX HORMONES › GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS › ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS › Quinoline derivatives
R02AA02	RESPIRATORY SYSTEM › THROAT PREPARATIONS › THROAT PREPARATIONS › Antiseptics

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Inflammatory marker increased	121.6
Stress	68.5
Exposure during pregnancy	61.9
Transposition of the great vessels	57.5
Foetal exposure during pregnancy	56.7
Musculoskeletal stiffness	55.1
Irritable bowel syndrome	53.5

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Dequalinium is on its molecule page.

• Molecular formula: C₃₀H₄₀N₄
• Molecular weight: 456.68 g/mol
• CAS number: 6707-58-0
• InChIKey: PCSWXVJAIHCTMO-UHFFFAOYSA-P
• PubChem CID: 2993

CC1=[N+](CCCCCCCCCC[N+]2=C(C)C=C(N)C3=CC=CC=C23)C2=CC=CC=C2C(N)=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Dequalinium work?

Its molecular targets in DrugCentral include Kcnn3, Kcnn2 (blocker), CNGA1 (blocker) and KCNN1 (blocker).

What is the chemical formula of Dequalinium?

Dequalinium has the molecular formula C30H40N4 and a molecular weight of 456.68 g/mol.

Sources

• DrugCentral drug card 4376 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL121663 — compound record and bioactivity
• PubChem CID 2993 — chemical identifiers
• DrugBank DB04209 — drug record
• FDA UNII E7QC7V26B8 — substance identity
• UniProt P29973 (CNGA1) — target protein
• UniProt Q92952 (KCNN1) — target protein
• UniProt Q9UGI6 (KCNN3) — target protein
• UniProt Q16280 (CNGA2) — target protein
• UniProt P17252 (PRKCA) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.