About Protein kinase C alpha type
Protein kinase C alpha type (PRKCA) is a protein
from Homo sapiens identified by UniProt accession
P17252, 672 residues long.
MolForge cross-references it against 0 known binders and
698 disease associations.
Target properties
| Protein name | Protein kinase C alpha type |
|---|
| UniProt accession | P17252 |
|---|
| Gene | PRKCA |
|---|
| Organism | Homo sapiens |
|---|
| Length | 672 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (12)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (698)
Diseases linked to this target (Open Targets).
- acute myeloid leukemia · score 0.51
- electrocardiography · score 0.50
- mast-cell leukemia · score 0.47
- QRS duration · score 0.46
- QT interval · score 0.45
- hypertrophic cardiomyopathy · score 0.44
- body height · score 0.43
- QRS complex · score 0.43
- neoplasm · score 0.42
- mathematical ability · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P17252-F1 | alphafold | PREDICTED | 86.38 | — |
Amino-acid sequence (672 residues)
MADVFPGNDS TASQDVANRF ARKGALRQKN VHEVKDHKFI ARFFKQPTFC SHCTDFIWGF GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGPDTDDPRS KHKFKIHTYG SPTFCDHCGS LLYGLIHQGM KCDTCDMNVH KQCVINVPSL CGMDHTEKRG RIYLKAEVAD EKLHVTVRDA KNLIPMDPNG LSDPYVKLKL IPDPKNESKQ KTKTIRSTLN PQWNESFTFK LKPSDKDRRL SVEIWDWDRT TRNDFMGSLS FGVSELMKMP ASGWYKLLNQ EEGEYYNVPI PEGDEEGNME LRQKFEKAKL GPAGNKVISP SEDRKQPSNN LDRVKLTDFN FLMVLGKGSF GKVMLADRKG TEELYAIKIL KKDVVIQDDD VECTMVEKRV LALLDKPPFL TQLHSCFQTV DRLYFVMEYV NGGDLMYHIQ QVGKFKEPQA VFYAAEISIG LFFLHKRGII YRDLKLDNVM LDSEGHIKIA DFGMCKEHMM DGVTTRTFCG TPDYIAPEII AYQPYGKSVD WWAYGVLLYE MLAGQPPFDG EDEDELFQSI MEHNVSYPKS LSKEAVSVCK GLMTKHPAKR LGCGPEGERD VREHAFFRRI DWEKLENREI QPPFKPKVCG KGAENFDKFF TRGQPVLTPP DQLVIANIDQ SDFEGFSYVN PQFVHPILQS AV
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