About Small conductance calcium-activated potassium channel protein 3
Small conductance calcium-activated potassium channel protein 3 (KCNN3) is a protein
from Homo sapiens identified by UniProt accession
Q9UGI6, 731 residues long.
MolForge cross-references it against 0 known binders and
162 disease associations.
Target properties
| Protein name | Small conductance calcium-activated potassium channel protein 3 |
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| UniProt accession | Q9UGI6 |
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| Gene | KCNN3 |
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| Organism | Homo sapiens |
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| Length | 731 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (162)
Diseases linked to this target (Open Targets).
- Zimmermann-Laband syndrome · score 0.72
- atrial fibrillation · score 0.45
- atrial flutter · score 0.38
- birth weight · score 0.34
- cardiac arrhythmia · score 0.34
- genetic disorder · score 0.34
- urate measurement · score 0.28
- heel bone mineral density · score 0.28
- chronic obstructive pulmonary disease · score 0.28
- parental genotype effect measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UGI6-F1 | alphafold | PREDICTED | 67.75 | — |
Amino-acid sequence (731 residues)
MDTSGHFHDS GVGDLDEDPK CPCPSSGDEQ QQQQQQQQQQ QPPPPAPPAA PQQPLGPSLQ PQPPQLQQQQ QQQQQQQQQQ PPHPLSQLAQ LQSQPVHPGL LHSSPTAFRA PPSSNSTAIL HPSSRQGSQL NLNDHLLGHS PSSTATSGPG GGSRHRQASP LVHRRDSNPF TEIAMSSCKY SGGVMKPLSR LSASRRNLIE AETEGQPLQL FSPSNPPEIV ISSREDNHAH QTLLHHPNAT HNHQHAGTTA SSTTFPKANK RKNQNIGYKL GHRRALFEKR KRLSDYALIF GMFGIVVMVI ETELSWGLYS KDSMFSLALK CLISLSTIIL LGLIIAYHTR EVQLFVIDNG ADDWRIAMTY ERILYISLEM LVCAIHPIPG EYKFFWTARL AFSYTPSRAE ADVDIILSIP MFLRLYLIAR VMLLHSKLFT DASSRSIGAL NKINFNTRFV MKTLMTICPG TVLLVFSISL WIIAAWTVRV CERYHDQQDV TSNFLGAMWL ISITFLSIGY GDMVPHTYCG KGVCLLTGIM GAGCTALVVA VVARKLELTK AEKHVHNFMM DTQLTKRIKN AAANVLRETW LIYKHTKLLK KIDHAKVRKH QRKFLQAIHQ LRSVKMEQRK LSDQANTLVD LSKMQNVMYD LITELNDRSE DLEKQIGSLE SKLEHLTASF NSLPLLIADT LRQQQQQLLS AIIEARGVSV AVGTTHTPIS DSPIGVSSTS FPTPYTSSSS C
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