Cepharanthine

Drug profile

Key facts

Cepharanthine is a drug catalogued in DrugCentral. It was first approved by the PMDA in 1951. DrugCentral lists 6 molecular targets, including REP, KCNN3 and KCNN2. Recorded indications include Alopecia, Aptyalism, Leukopenia and Snake bite - wound.

• Molecular targets: REP, KCNN3, KCNN2 and TPR (6 listed in DrugCentral).
• Indications: Alopecia, Aptyalism, Leukopenia and Snake bite - wound.
• Molecular formula: C37H38N2O6; molecular weight 606.72 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (4)

• Alopecia
• Aptyalism
• Leukopenia
• Snake bite - wound

Off-label uses (1)

• Coronavirus infection

Mechanism & targets

Molecular targets (6)

Target	Gene	Action	Activity
Replicase polyprotein 1ab	REP	unknown	IC50 7.00
Small conductance calcium-activated potassium channel protein 3	KCNN3	unknown	Ki 5.96
Small conductance calcium-activated potassium channel protein 2	KCNN2	unknown	Ki 5.88
Trypanothione reductase	TPR	unknown	Ki 5.12
5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	inhibitor	—
Nuclear factor NF-kappa-B p105 subunit	NFKB1	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1951-01-01	PMDA	—	—

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Cepharanthine is on its molecule page.

• Molecular formula: C₃₇H₃₈N₂O₆
• Molecular weight: 606.72 g/mol
• CAS number: 481-49-2
• InChIKey: YVPXVXANRNDGTA-WDYNHAJCSA-N
• PubChem CID: 10206

COC1=C2OC3=CC=C(C[C@@H]4N(C)CCC5=CC6=C(OCO6)C(OC6=C(OC)C=C7CCN(C)[C@H](CC(C=C1)=C2)C7=C6)=C45)C=C3

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Cepharanthine used for?

DrugCentral lists the following indications for Cepharanthine: Alopecia, Aptyalism, Leukopenia and Snake bite - wound.

How does Cepharanthine work?

Its molecular targets in DrugCentral include REP, KCNN3, KCNN2 and TPR.

When was Cepharanthine first approved?

Cepharanthine was first approved by the PMDA in 1951.

What is the chemical formula of Cepharanthine?

Cepharanthine has the molecular formula C37H38N2O6 and a molecular weight of 606.72 g/mol.

Sources

• DrugCentral drug card 5375 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2074948 — compound record and bioactivity
• PubChem CID 10206 — chemical identifiers
• DrugBank DB16824 — drug record
• FDA UNII 7592YJ0J6T — substance identity
• UniProt Q9UGI6 (KCNN3) — target protein
• UniProt Q9H2S1 (KCNN2) — target protein
• UniProt Q13131 (PRKAA1) — target protein
• UniProt P19838 (NFKB1) — target protein

How this page is built: methodology · editorial policy & corrections.