Small conductance calcium-activated potassium channel protein 2 (KCNN2)
Homo sapiens — UniProt Q9H2S1
Data last refreshed: (UniProt release unknown)
Key facts
Small conductance calcium-activated potassium channel protein 2 (KCNN2) is a protein from Homo sapiens identified by UniProt accession Q9H2S1, 579 residues long. MolForge cross-references it against 2 known binders and 369 disease associations.
- UniProt accession: Q9H2S1; gene symbol KCNN2.
- Organism: Homo sapiens.
- Length: 579 amino acids.
- Approved drugs acting on it (DrugCentral): Tubocurarine.
- Top disease associations (Open Targets): Intellectual disability, Seizure and Global developmental delay.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Small conductance calcium-activated potassium channel protein 2 |
|---|---|
| UniProt accession | Q9H2S1 |
| Gene | KCNN2 |
| Organism | Homo sapiens |
| Length | 579 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (369)
Diseases linked to this target (Open Targets).
- Intellectual disability · score 0.57
- Seizure · score 0.56
- Global developmental delay · score 0.52
- Autistic behavior · score 0.50
- Intellectual disability, mild · score 0.46
- movement disorder · score 0.46
- myoclonus-dystonia syndrome · score 0.46
- Motor tics · score 0.45
- cerebellar ataxia · score 0.45
- atrial fibrillation · score 0.44
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H2S1-F1 | alphafold | PREDICTED | 76.48 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H2S1.
Amino-acid sequence (579 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target KCNN2?
DrugCentral lists 1 approved drug whose mechanism of action is KCNN2: Tubocurarine.
Which diseases are associated with KCNN2?
The strongest Open Targets associations for KCNN2 are Intellectual disability, Seizure, Global developmental delay, Autistic behavior and Intellectual disability, mild.
How long is the KCNN2 protein?
The Homo sapiens KCNN2 protein (UniProt Q9H2S1) is 579 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H2S1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H2S1 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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